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胃癌患者EB病毒感染与Cyclin D1基因表达的相关性
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胃癌患者,,疱疹病毒4型,人;胃肿瘤;癌基因蛋白质类,胃癌患者EB病毒感染与CyclinD1基因表达的相关性,1材料和方法,结果,3讨论,【参考文献】
     Relativity between EBV infection and expression of Cyclin D1 in gastric carcinoma patients

    LI ShuYing1, ZHANG Ke2, ZHOU TianJi1

    1Department of Microbiology, 2Department of Correspondence in Adult Education College, North China Coal Medical College, Tangshan 063000, China

    【Abstract】 AIM:To investigate the relativity between the EpsteinBarr Virus (EBV) infection and the expression of Cyclin D1 in gastric carcinoma (GC) patients. METHODS: EBER1 in 217 cases of GC was detected with in situ hybridization. Then, EBV positive and negative GC cases were selected for analysis of the expression of Cyclin D1 by immunohistochemistry. RESULTS: In 217 GC cases there were 23 cases with EBER1 positive expression. The expression of Cyclin D1 was higher in the EBV positive GC than that in the EBV negative (P<0.01). CONCLUSION: EBV infection in GC may upregulate the expression of Cyclin D1. ......

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