摘要:目的 探讨2型糖尿病与骨质疏松症的相关因素及发生机制。 方法 2型糖尿病患者43例和正常对照43例，采用单光子吸收法测定尺、桡骨骨密度(BMD)，以酶联免疫法分别测定空腹血清骨钙素(BGP)及晨尿中脱氧吡啶啉(DPD)值。 结果 2型糖尿病组的BMD低于正常对照组，BGP和DPD高于正常对照组。两组比较差异有非常显著性(P<0.01)。 结论 2型糖尿病患者骨形成减少，骨吸收增加，骨质疏松症发生率高。及早对糖尿病性骨质疏松进行防治有重要意义。

    关键词:2型糖尿病;骨密度;骨钙素;尿脱氧吡啶啉

    Observation on the bone density and bone metabolism of43patients with type2diabetes mellitus.

    SUN Sheng-hua，YUN Wu，SONG Qin-hua，et al.

    (Affilaited Hospital of Hainan Medical College，Haikou570102，Hainan，P.R.China)

    Abstract:Objective To discuss the factors associated with osteoporosis in patients with type2diabetes mellitus and pathogene-sis. Methods 43patients with type2diabetes mellitus including23males and20females and healthy control inclduing21males and22females were selected.Single photon absorption was ued to determine the bone mineral density(BMD)of the elbow bone and radial bone.ELISA was used to determine serum osteocalcin(BGP) ......