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Infectious Diseases of the Fetus and Newborn Infant
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     Infectious Diseases of the Fetus and Newborn Infant is an excellent source of information on infections in newborns, especially those transmitted from mother to baby. The stated goal of the editors is "to provide a complete, critical, and contemporary review" of existing infections that affect the fetus and the newborn. There are five major sections: General Information; Bacterial Infections; Viral Infections; Protozoan, Helminth, and Fungal Infections; and Diagnosis and Management. A chapter on developmental immunology and host defense by Christopher B. Wilson and David B. Lewis is a remarkably concise, detailed, and informative mini-monograph on this topic. The goal of the editors is achieved admirably in chapters that cover the most important agents that are transmitted from mother to baby in the United States — syphilis, group B streptococcus, the human immunodeficiency virus, cytomegalovirus, herpes simplex virus, parvovirus, rubella virus, and toxoplasma. The chapter on group B streptococcal infections is outstanding; it combines a readable discussion of the microbiology of the organism and the pathogenesis of infection with a review of information on the prevention and management of infection.

    One of the strengths of this textbook is that most of its chapters provide information on the latest research, combined with up-to-date information on the management of patients' care. The chapter on toxoplasmosis will be of great interest to researchers. It is about three times as long as the chapters on other major congenital infections, because it includes a detailed discussion of the historical evolution of knowledge about this infection. In the section on bacterial infections, there are chapters on specific infectious agents and clinical categories of infection — sepsis, meningitis, and organ-system infections. The chapters organized according to clinical category present information clearly and in a format that will be appreciated by those who provide care to newborns.

    In the 30 years that have elapsed between the first and sixth editions of Infectious Diseases of the Fetus and Newborn Infant, there have been notable changes in the way that medical information is acquired and evaluated. The importance of the scientific validity of clinical data (evidence-based medicine) is now widely acknowledged. In addition, expert panels often define standards of care with recommendations on diagnosis and treatment. The availability of excellent information (including guidelines from expert panels) from electronic sources is a fact of life that traditional textbooks would do well to acknowledge. This book would have been greatly improved if it had incorporated more explicit use of evidence-based medicine and references to the recommendations or treatment guidelines endorsed by expert panels. Its value would also have been increased by the inclusion of consistent references to electronic sources of information, especially those from which readers could obtain the latest management recommendations endorsed by the American Academy of Pediatrics, the American College of Obstetrics and Gynecology, the Infectious Diseases Society of America, or expert panels convened by the National Institutes of Health or the Centers for Disease Control and Prevention. An electronic or CD-ROM edition of the book would also be attractive to many readers.

    Shortcomings notwithstanding, Infectious Diseases of the Fetus and Newborn Infant is a classic textbook. Its editors and authors are the scientists and clinicians whose work has advanced knowledge of maternal, fetal, and neonatal infections. For 30 years, this textbook has been the single best source of information in this area.

    Robert F. Pass, M.D.

    University of Alabama School of Medicine

    Birmingham, AL 35233(Sixth edition. Edited by )