[摘 要] 目的: 探讨微循环障碍在急性坏死性胰腺炎大鼠中的作用，同时观察川芎嗪对急性坏死性胰腺炎肠黏膜 损害的干预效应。方法: SD大鼠192只，随机分为对照组(C组)、胰腺炎组(P组)、川芎嗪治疗组(T组)，每组64只。采用放射性生物微球技术在制模后0.5，2，6 h及12 h分别测定肠血流量;对胰腺、肠组织进行病理评分并观察肠组织的MPO活性、白细胞浸润情况。 结果: P组与C组相比: P组各时相肠的血流量均明显降低( P <0.01 );病理 改变及白细胞浸润明显加重;肠组织MPO活性明显增加(P<0.01 )。T组与P组相比:T组2 h起肠血流量较P组均 明显增加(P<0.01 );各时相病理改变及白细胞浸润明显减轻;组织MPO活性明显下降(P<0.05 或 P <0.01 )。肠组织血流量与肠组织MPO活性间呈显著负相关，与肠组织损伤程度呈显著负相关。结论: 微循环障碍在急性坏死性胰腺炎时肠组织损伤中起着重要的作用。川芎嗪可以改善微循环，减轻胰腺及肠黏膜损害。

    [关键词] 胰腺炎; 微循环; 川芎嗪; 肠黏膜损害

    Protection of ligustrazine to the mucosa of small intestine on acute necrotizing pancreatitis in rats

    QU Jian-guo，DANG Sheng-chun，ZHANG Jian-xin

    (Department of General Surgery， the Affiliated Hospital of Jiangsu University， Zhenjiang Jiangsu 212001， China)

    [Abstract] Objective: To evaluate the role of microcirculatory disorder(MCD) ，and study the therapeu- tic effectiveness of ligustrazine to the mucosa of intestine on acute necrotizing pancreatitis in rats. Methods: A total of 192 SD rats were divided into three groups at random(each with 64 rats): control group (C); pancreatitis (P) group; ligustrazine treatment(T) group. Radioactive biomicrosphere technique(RMT) was used to measure the intestinal blood flow at 0.5h、2h、6h and 12h after the induction of ANP. The sam- ples of pancreas ......