[摘 要] 目的: 通过检测急性心肌梗死(AMI)介入治疗患者体内晚期蛋白氧化产物(AOPP)的水平，观察氧化应激在体内的变化过程。 方法: 入选74例AMI[28例急诊经皮冠状动脉介入治疗(PCI)和46例择期经皮冠状动脉介入治疗]及21例非冠心病(均经造影证实)患者，分别采集外周静脉血标本入院即刻、24 h和48 h 3个时间点，在紫外荧光340 nm及酸性条件下测定血清标本的光密度。结果: AOPP浓度AMI择期PCI组(236.42±30.41)μmol/L与 AMI急诊PCI组(97.58±23.41)μmol/L( P <0.01)及非冠心病组(57.41±13.60 )μmol/L( P <0.05)均有显著性差异( P <0.01)，AMI择期PCI组明显升高，而AMI急诊PCI组(97.58±23.41)μmol/L，与非冠心病组无显著差异。结 论: 氧化应激是AMI发生发展过程中的重要环节，AMI择期PCI患者血清AOPP浓度显著升高，AMI发病早期(3～12h)内的积极干预(介入及药物治疗)可抑制AOPP大量生成。

    [关键词] 急性心肌梗死; 氧化产物; 经皮冠状动脉介入术

    Level of Advanced Oxidation Protein Products in patients with acute myocardial infarction who underwent PCI

    DENG Xin-tao，HE Qian， ZHAO Jian-xiang，MA Geng-shan， FENG Yi ， WANG Ji-hui， HU Shan-you

    (1.Department of Cardiology， Xinghua People′s Hospital，Xinghua Jiangsu 225700; 2.Department of Cardiology， Zhongda Hospital， Southeast University， Nanjing Jiangsu 210009，China)

    [Abstract] Objective: To examine the advanced oxidation protein products(AOPP) in patients with a- cute myocardial infarction (AMI) who underwent PCI and discuss the development of AOPP in AMI pa- tients . Methods: AOPP were determined by measurements of optical density (OD) at 340 nm under acidic conditions in the plasma of 74 AMI patients (include 28 patients underwent emergency PCI ......