希罗达术前化疗对结直肠癌组织TP/PD-ECGF表达和血管生成的影响
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余细球
结直肠癌;胸苷磷酸化酶,血小板衍化内皮细胞生长因子;微血管密度;希罗达,余细球,通讯作者:,Preoperativeadministrationofxelodaontheangiogenesisandexpressionoft
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余细球, 深圳市罗湖区人民医院消化内科 广东省深圳市 518000
通讯作者: 余细球, 518001, 广东省深圳市罗湖区友谊路47号, 罗湖区人民医院消化内科. yuxiqiu0001@hotmail.com
电话: 0755-82203083-1533
收稿日期: 2006-08-01 接受日期: 2006-08-22
Preoperative administration of xeloda on the angiogenesis and expression of thymidine phosphorylase/platelet-derived endothelial cell growth factor in colorectal cancer
Xi-Qiu Yu
Xi-Qiu Yu,Department of Gastroenterology, Luohu Hospital of Shenzhen City, Shenzhen 518000, Guangdong Province, China
Correspondence to:Xi-Qiu Yu, Department of Gastroenterology, Luohu Hospital of Shenzhen City, Shenzhen 518001, Guangdong Province, China. yuxiqiu0001@hotmail.com
Received:2006-08-01 Accepted:2006-08-22
Abstract
AIM: To investigate the effect of capecitabine (xeloda) by preoperation administration on the microvessel density (MVD) and expression of thymidine phosphorylase/platelet-derived endothelial cell growth factor (TP/PD-ECGF) in patients with colorectal cancer.
METHODS: Immunohistochemical staining of CD34 and TP/PD-ECGF monoclonal antibodies was performed in 32 colorectal cancer patients with preoperative xeloda chemotherapy and 25 cases without chemotherapy (served as controls), and then the expression of TP/PD-ECGF and MVD were analyzed.
RESULTS: The positive rate of TP/PD-ECGF expression in patients with chemotherapy was significantly lower than that in the controls (31.2% vs 60.0%, P < 0.05). As compared with that in the controls, the value of MVD in patients with chemotherapy was markedly different (20.7 ± 8.5 vs 42.3 ± 7.8, P < 0.05).
CONCLUSION: Preoperation chemotherapy of xeloda can decrease the activity of TP/PD-ECGF and inhibit the angiogenesis in colorectal cancer.
Key Words: Colorector cancer; Thymidine phosphorylase/platelet-derived endothelial cell growth factor; Microvessel density; Xeloda
Yu XQ. Preoperative administration of xeloda on the angiogenesis and expression of thymidine phosphorylase/platelet-derived endothelial cell growth factor in colorectal cancer ......
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