钙离子信号调节亲环素配体研究进展
http://www.100md.com
程勇前, 成 军
钙离子信号调节亲环素配体;信号转导;相互作用;进展,程勇前,程勇前,成军,通讯作者:,Researchprogressincalcium-modulatingcyclophilinligand,Yong-QianCheng,JunCheng
 |
| 第1页 |
参见附件(776KB，5页)。
程勇前, 中国人民解放军302医院病毒性肝炎研究室 北京市 100039
程勇前, 军事医学科学院在读博士研究生 北京市 100850
成军, 北京地坛医院 北京市 100011
通讯作者: 程勇前, 100039, 北京市, 中国人民解放军302医院病毒性肝炎研究室. cheng.yq@126.com
电话: 010-66933392
收稿日期: 2006-10-09 接受日期: 2006-10-18
Research progress in calcium-modulating cyclophilin ligand
Yong-Qian Cheng, Jun Cheng
Yong-Qian Cheng,Department of Viral Hepatitis, the 302 Hospital of Chinese PLA, Beijing 100039, China
Yong-Qian Cheng,Doctor in Reading, Academy of Military Medical Sciences, Beijing 100850, China
Jun Cheng,Beijing Ditan Hospital, Beijing 100039, China
Correspondence to:Yong-Qian Cheng, Department of Viral Hepatitis, the 302 Hospital of Chinese PLA, Beijing 100039, China. cheng.yq@126.com
Received:2006-10-09 Accepted:2006-10-18
Abstract
Calcium-modulating cyclophilin ligand (CAML) is a ubiquitous protein that has been implicated in signal transduction, cell apoptosis, immune regulation and virus infection, although its role and mechanism of action are unknown. Many proteins, including transmembrane activator and CAML interactor, epidermal growth factor receptor, angiotensin 1 receptor-associated protein, immediate early gene X-1 protein, p56Lck, fibrocystin (coded by PKHD1), and Kaposi's sarcoma-associated herpesvirus protein, have been proved to be interacting with CAML. In this article, the recent development of CAML-associated study is reviewed.
Key Words: Calcium-modulating cyclophilin ligand; Signal transduction; Interaction; Progress
Cheng YQ, Cheng J. Research progress in calcium-modulating cyclophilin ligand. Shijie Huaren Xiaohua Zazhi 2007;15(1):56-60
摘要
钙离子信号调节亲环素配体(CAML)作为亲环素B的结合蛋白于1994年被首次发现, 尽管其具体作用机制目前还不十分清楚, 但许多研究已证实其在T细胞受体及钙离子信号转导、细胞凋亡、免疫调节以及病毒感染等方面具有重要作用. 目前已经报道与其相互作用的蛋白主要有: 跨膜激活剂及钙调亲环素配体相互作用分子(transmembrane activator and CAML interactor, TACI)、EGF受体, 血管紧张素ⅡⅠ型受体相关蛋白(AT1 receptor-associated protein, ATRAP)、人立早基因(immediate early gene X-1, IEX-1)、淋巴细胞特异蛋白质酪氨酸激酶(p56Lck)、常染色体隐性遗传性多囊肾疾病的相关基因PKHD1编码的蛋白fibrocystin, 以及霍普金氏肉瘤相关疱疹病毒K7蛋白(KSHV)等 ......
您现在查看是摘要介绍页，详见PDF附件(776KB，5页)。