Acquisition of Helicobacter pylori infection after outbreaks of gastroenteritis: prospective cohort survey in institutionalised young people
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《英国医生杂志》
1 Inserm E9919-Université de Lille II JE 2225, Institut de Biologie de Lille, France, 2 Centre Antoine de Saint-Exupéry, Vendin-le-Vieil, France, 3 Clinique de Pédiatrie, H?pital Jeanne de Flandre, Lille, France
Correspondence to: P Vincent, Laboratoire de Bactériologie-Hygiène, Centre Hospitalier Régional et Universitaire, H?pital Calmette, 1 Boulevard J Leclercq, 59037 Lille Cedex, France p-vincent@chru-lille.fr
Introduction
An association was found between gastroenteritis and subsequent acquisition of H pylori infection in cohabiting young people. Despite the limitations of the non-invasive test used to determine the presence of H pylori, time and space clustering shows that conversions were not observed by chance. This chronological link suggests that, under usual conditions of life, there might be a causal link between outbreaks of gastroenteritis and transmission of H pylori.5
We thank Marie-Jeanne Capron, Christine Guillemant, and the nursing staff of Centre Antoine de Saint-Exupéry, Vendin-le-Vieil, for help during the study, Danielle Samaille, Institut Pasteur de Lille, for transport of samples, and M Simonet for critical reading of the manuscript.
Contributors: RL performed the literature search, data collection, and biological and epidemiological analysis and interpretation, and drafted the report. PV was the academic supervisor of RL. PV initiated the project, was responsible for funding and design, organised the collection of samples, helped interpret the results, and wrote and revised the report; he will act as guarantor for the paper. PhP and PP were responsible for the care of the patients and management of the institution. FG was involved in the design of the study and advised on medical issues and discrepancies during the study. All authors critically analysed the data and wrote the paper.
Funding: RL received a scholarship from Laboratoire Gallia.
Competing interests: None declared.
Ethical approval: This study was approved by the local ethics committee, Vendin-le-Vieil.
References
Thomas JE, Gibson GR, Darboe MK, Dale A, Weaver LT. Isolation of Helicobacter pylori from human faeces. Lancet 1992;340: 1194-5.
Parsonnet J, Shmuely H, Haggerty T. Fecal and oral shedding of Helicobacter pylori from healthy infected adults. JAMA 1999;282: 2240-5.
Leung WK, Siu KL, Kwok CK, Chan SY, Sung R, Sung JJ. Isolation of Helicobacter pylori from vomitus in children and its implication in gastro-oral transmission. Am J Gastroenterol 1999;94: 2881-4.
Gisbert JP, Pajares JM. Diagnosis of Helicobacter pylori infection by stool antigen determination: a systematic review. Am J Gastroenterol 2001;96: 2829-38.
Hill AB. The environment and disease: association and causation. Proc R Soc Med 1965;58: 295-300.(Rémi Laporte, resident in)
Correspondence to: P Vincent, Laboratoire de Bactériologie-Hygiène, Centre Hospitalier Régional et Universitaire, H?pital Calmette, 1 Boulevard J Leclercq, 59037 Lille Cedex, France p-vincent@chru-lille.fr
Introduction
An association was found between gastroenteritis and subsequent acquisition of H pylori infection in cohabiting young people. Despite the limitations of the non-invasive test used to determine the presence of H pylori, time and space clustering shows that conversions were not observed by chance. This chronological link suggests that, under usual conditions of life, there might be a causal link between outbreaks of gastroenteritis and transmission of H pylori.5
We thank Marie-Jeanne Capron, Christine Guillemant, and the nursing staff of Centre Antoine de Saint-Exupéry, Vendin-le-Vieil, for help during the study, Danielle Samaille, Institut Pasteur de Lille, for transport of samples, and M Simonet for critical reading of the manuscript.
Contributors: RL performed the literature search, data collection, and biological and epidemiological analysis and interpretation, and drafted the report. PV was the academic supervisor of RL. PV initiated the project, was responsible for funding and design, organised the collection of samples, helped interpret the results, and wrote and revised the report; he will act as guarantor for the paper. PhP and PP were responsible for the care of the patients and management of the institution. FG was involved in the design of the study and advised on medical issues and discrepancies during the study. All authors critically analysed the data and wrote the paper.
Funding: RL received a scholarship from Laboratoire Gallia.
Competing interests: None declared.
Ethical approval: This study was approved by the local ethics committee, Vendin-le-Vieil.
References
Thomas JE, Gibson GR, Darboe MK, Dale A, Weaver LT. Isolation of Helicobacter pylori from human faeces. Lancet 1992;340: 1194-5.
Parsonnet J, Shmuely H, Haggerty T. Fecal and oral shedding of Helicobacter pylori from healthy infected adults. JAMA 1999;282: 2240-5.
Leung WK, Siu KL, Kwok CK, Chan SY, Sung R, Sung JJ. Isolation of Helicobacter pylori from vomitus in children and its implication in gastro-oral transmission. Am J Gastroenterol 1999;94: 2881-4.
Gisbert JP, Pajares JM. Diagnosis of Helicobacter pylori infection by stool antigen determination: a systematic review. Am J Gastroenterol 2001;96: 2829-38.
Hill AB. The environment and disease: association and causation. Proc R Soc Med 1965;58: 295-300.(Rémi Laporte, resident in)