前列腺癌(Pca)；_前列腺特异性抗原(PSA);

晚期前列腺癌药物去势中Gleason评分、血清PSA与疗效相关性研究

http://www.100md.com 《新疆医科大学学报》 2007年第1期

前列腺癌(Pca)；,前列腺特异性抗原(PSA);,Gleason评分,,前列腺癌(Pca)；,前列腺特异性抗原(PSA);,Gleason评分,关键词：前列腺癌(Pca)；前列腺特异性抗原(PSA);Gleason评分,1

     摘要: 目的：探讨晚期前列腺癌(Pca)患者药物去势治疗过程中疗效与Gleason评分及血清前列腺特异性抗原(PSA)的相关性。方法：选择33例晚期Pca患者，给予黄体激素释放激素类似物(LHRHA)+抗雄激素药物进行药物去势治疗，根据Gleason评分分为2~5分组、6~7分组、8~10分组，对3组血清PSA变化进行分析。结果： Gleason评分6~7分组的病人在治疗后3个月内血清PSA值下降最快，治疗后6个月时Gleason评分2~5分组病人血清PSA值恢复正常，而Gleason评分6~7分组与8~10分组病人血清PSA值则接近正常值范围。不同Gleason评分组间血清PSA水平差异有统计学意义(F=5.396， P<0.05)。结论：(1)Gleason评分、血清PSA水平与晚期Pca患者行药物去势疗法疗效有密切关系。(2)血清PSA变化是监测Pca复发与评价疗效的可靠瘤标。

    关键词：前列腺癌(Pca)；前列腺特异性抗原(PSA); Gleason评分

    relative analysis on the efficacy of medical castration in the treatment of metastatic prostate cancer patients to Gleason score and serum PSA level

    HUANG Suxi, WANG Yujie, SONG GuangLu, et al

    (Department of Urology, First Affiliated Hospital, Xinjiang Medical Universty,Urumqi 830000, China)

    Abstract：Objective: To probe into the correlation of Gleason score and serum PSA level during medical castration in metastatic prostate cancer patients. Methods: We treated metastatic prostate cancer patients with luteinizing hormonereleasing hormone analog, (LHRHA) and androgen ablation drug (Flutamide), and combined with the change of Gleason score and serum PSA level, We have a statistical analysis elevate the efficacy of treatment. Results: The levels of the serum PSA during the treatment significantly decreased in 3 months among the groups of Gleason score between 6~7. The level of the serum PSA during the treatment returned to normal in 6 months among the groups of Gleason score between 2~5, but the groups of Gleason score between 6~7 and 8~10 were near to normal and the level of serum of PSA among different groups of Gleason score with significantly different (F=5.396, P<0.05). Statistically significant differences were found in those. Conclusions: (1) The Gleason score and the level of the serum PSA have a close relation to the efficacy of medical castration in the treatment of metastatic prostate cancer patients. (2)The change of PSA level is a valuable marker for watching the recurrent and effective of tumor. ......

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