血管内皮生长因子受体与肝细胞癌血管生成关系的研究进展
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赵一鸣, 王 鲁
血管内皮生长因子;受体;血管生成;肝细胞肝癌,赵一鸣,王鲁,通讯作者:,电话:,收稿日期:,接受日期:,Advancementoftherelationshipbetweenvascularendothelialgrowthfactor
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赵一鸣, 王鲁, 复旦大学附属中山医院肝外科 复旦大学肝癌研究所 上海市 200032国家自然科学基金资助项目, No. 30571800
高等学校全国优秀博士学位论文作者专项资金资助项目, No. 200263
上海市科技发展基金资助项目, No. 03QD14008
通讯作者: 王鲁, 200032, 上海市, 复旦大学附属中山医院肝外科, 复旦大学肝癌研究所. wlu@zshospital.net
电话: 021-64041990-3058
收稿日期: 2006-12-12 接受日期: 2007-01-11
Advancement of the relationship between vascular endothelial growth factor receptors and angiogenesis of hepatocellular carcinoma
Yi-Ming Zhao, Lu Wang
Yi-Ming Zhao, Lu Wang,Department of General Surgery, Zhongshan Hospital; Liver Cancer Institute, Fudan University, Shanghai 200032, China
Supported by National Natural Science Foundation of China, No. 30571800, the Foundation for the Author of National Excellent Doctoral Dissertation of China, No. 200263, and the Science and Technology Development Foundation of Shanghai Municipality, No. 03QD14008
Correspondence to: Lu Wang, Department of General Surgery, Zhongshan Hospital; Liver Cancer Institute, Fudan University, Shanghai 200032,China. wlu@zshospital.net
Received: 2006-12-12 Accepted: 2007-01-11
AbstractAngiogenesis is the basis of tumor growth and metastasis. Hepatocellular carcinoma is a kind of typical multivessel tumor, whose generation, progression and invasion are closely related with the angiogenesis. The angiogenesis is mainly regulated by angiogenins and anti-angiogenins, of which vascular endothelial growth factor (VEGF) and its receptor (VEGFR) are the most important. Different kinds of VEGFR have various functions in vivo, and VEGFR-1 (flt-1) and VEGFR-2 (flk-1) are involved in the angiogenesis HCC. Satisfactory effects have been obtained by the anti-angiogenic therapies targeting on VEGFR in laboratory studies, some of which have been launched in clinical experiments.
Key Words: Vascular endothelial growth factor; Receptor; Angiogenesis; Hepatocellular carcinoma
Zhao YM, Wang L. Advancement of the relationship between vascular endothelial growth factor receptors and angiogenesis of hepatocellular carcinoma. Shijie Huaren Xiaohua Zazhi 2007;15(6):596-600
摘要新生血管是肿瘤生长和转移的基础. 肝细胞肝癌是典型的多血管肿瘤, 其发生、发展、转移、侵袭都和血管生成密切相关. 血管的生成主要依靠血管生长因子和血管生长抑制因子的调控, 其中研究最多也是最重要的是血管内皮生长因子(VEGF)及其受体(VEGFR). VEGFR在机体内作用不同, 参与肝癌血管生长的主要是VEGFR-1(flt-1)和VEGFR-2(flk-1).针对VEGFR的抗肿瘤血管治疗在实验室取得了不错的疗效, 部分已经进入了临床试验.
关键词: 血管内皮生长因子; 受体; 血管生成; 肝细胞肝癌
赵一鸣, 王鲁. 血管内皮生长因子受体与肝细胞癌血管生成关系的研究进展. 世界华人消化杂志 2007;15(6):596-600
0 引言
原发性肝癌(肝细胞癌, 以下简称肝癌)目前是我国第二位癌症杀手[1]. 根治性切除后, 肝癌的5 a转移复发率为54.1%-61.5%, 根据复发病例分析, 肝癌切除后2-3 a内的复发为原发灶播散, 较晚期的复发为多中心发生, 而2 a内的累积复发数占总复发数的62.4%-77.8%[2]. 因此肝癌的转移成为限制肝癌生存率的最大障碍. El-Assal et al[3]分析了71位肝癌患者根治性切除的肿瘤标本和癌周肝组织中微血管密度(MVD)和血管内皮细胞生长因子(VEGF)的表达, 小肝癌(≤2 cm)的微血管密度明显低于直径2-5 cm的肝癌, MVD和肝内复发和无瘤生存率有密切关系, 而且通过多因素分析发现MVD是肝癌无瘤生存的独立预测指标. 因此可以认为肝癌的血管生成和转移复发有密切关系 ......
赵一鸣, 王鲁, 复旦大学附属中山医院肝外科 复旦大学肝癌研究所 上海市 200032国家自然科学基金资助项目, No. 30571800
高等学校全国优秀博士学位论文作者专项资金资助项目, No. 200263
上海市科技发展基金资助项目, No. 03QD14008
通讯作者: 王鲁, 200032, 上海市, 复旦大学附属中山医院肝外科, 复旦大学肝癌研究所. wlu@zshospital.net
电话: 021-64041990-3058
收稿日期: 2006-12-12 接受日期: 2007-01-11
Advancement of the relationship between vascular endothelial growth factor receptors and angiogenesis of hepatocellular carcinoma
Yi-Ming Zhao, Lu Wang
Yi-Ming Zhao, Lu Wang,Department of General Surgery, Zhongshan Hospital; Liver Cancer Institute, Fudan University, Shanghai 200032, China
Supported by National Natural Science Foundation of China, No. 30571800, the Foundation for the Author of National Excellent Doctoral Dissertation of China, No. 200263, and the Science and Technology Development Foundation of Shanghai Municipality, No. 03QD14008
Correspondence to: Lu Wang, Department of General Surgery, Zhongshan Hospital; Liver Cancer Institute, Fudan University, Shanghai 200032,China. wlu@zshospital.net
Received: 2006-12-12 Accepted: 2007-01-11
AbstractAngiogenesis is the basis of tumor growth and metastasis. Hepatocellular carcinoma is a kind of typical multivessel tumor, whose generation, progression and invasion are closely related with the angiogenesis. The angiogenesis is mainly regulated by angiogenins and anti-angiogenins, of which vascular endothelial growth factor (VEGF) and its receptor (VEGFR) are the most important. Different kinds of VEGFR have various functions in vivo, and VEGFR-1 (flt-1) and VEGFR-2 (flk-1) are involved in the angiogenesis HCC. Satisfactory effects have been obtained by the anti-angiogenic therapies targeting on VEGFR in laboratory studies, some of which have been launched in clinical experiments.
Key Words: Vascular endothelial growth factor; Receptor; Angiogenesis; Hepatocellular carcinoma
Zhao YM, Wang L. Advancement of the relationship between vascular endothelial growth factor receptors and angiogenesis of hepatocellular carcinoma. Shijie Huaren Xiaohua Zazhi 2007;15(6):596-600
摘要新生血管是肿瘤生长和转移的基础. 肝细胞肝癌是典型的多血管肿瘤, 其发生、发展、转移、侵袭都和血管生成密切相关. 血管的生成主要依靠血管生长因子和血管生长抑制因子的调控, 其中研究最多也是最重要的是血管内皮生长因子(VEGF)及其受体(VEGFR). VEGFR在机体内作用不同, 参与肝癌血管生长的主要是VEGFR-1(flt-1)和VEGFR-2(flk-1).针对VEGFR的抗肿瘤血管治疗在实验室取得了不错的疗效, 部分已经进入了临床试验.
关键词: 血管内皮生长因子; 受体; 血管生成; 肝细胞肝癌
赵一鸣, 王鲁. 血管内皮生长因子受体与肝细胞癌血管生成关系的研究进展. 世界华人消化杂志 2007;15(6):596-600
0 引言
原发性肝癌(肝细胞癌, 以下简称肝癌)目前是我国第二位癌症杀手[1]. 根治性切除后, 肝癌的5 a转移复发率为54.1%-61.5%, 根据复发病例分析, 肝癌切除后2-3 a内的复发为原发灶播散, 较晚期的复发为多中心发生, 而2 a内的累积复发数占总复发数的62.4%-77.8%[2]. 因此肝癌的转移成为限制肝癌生存率的最大障碍. El-Assal et al[3]分析了71位肝癌患者根治性切除的肿瘤标本和癌周肝组织中微血管密度(MVD)和血管内皮细胞生长因子(VEGF)的表达, 小肝癌(≤2 cm)的微血管密度明显低于直径2-5 cm的肝癌, MVD和肝内复发和无瘤生存率有密切关系, 而且通过多因素分析发现MVD是肝癌无瘤生存的独立预测指标. 因此可以认为肝癌的血管生成和转移复发有密切关系 ......
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