法莫替丁及西咪替丁对Oddi括约肌压力变化的影响
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张小薄, 吴硕东, 孔 静, 王 伟
Oddi括约肌;法莫替丁;西咪替丁;测压;运动性,张小薄,吴硕东,孔静,王伟,通讯作者:,电话:, 传真:,收稿日期:,接受日期:,Effectsoffamotidineandcimetidineonhumansphincter
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张小薄, 吴硕东, 孔静, 王伟, 中国医科大学盛京医院普外科 辽宁省沈阳市 110004
通讯作者: 吴硕东, 110004, 辽宁省沈阳市和平区三好街36号, 中国医科大学盛京医院普外科. wusd@cmu2h.com
电话: 024-83955058 传真: 024-83956291
收稿日期: 2006-10-26 接受日期: 2006-12-18
Effects of famotidine and cimetidine on human sphincter of Oddi pressure
Xiao-Bo Zhang, Shuo-Dong Wu, Jing Kong, Wei Wang
Xiao-Bo Zhang, Shuo-Dong Wu, Jing Kong, Wei Wang,Department of General Surgery, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China
Correspondence to:Shuo-Dong Wu, Department of General Surgery, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. wusd@cmu2h.com
Received:2006-10-26 Accepted:2006-12-18
Abstract
AIM:To assess the effects of famotidine and cimetidine at routine dosages on human sphincter of Oddi (SO) motility by choledochoscope manometry.
METHODS: A total of 20 patients with T tubes after cholecytectomy and choledochotomy were randomly divided into famotidine group and cimetidine group (n = 10). The pressure of duodenum (DP), basal pressure of SO (SOBP), contractive amplitude of SO (SOCA), contractive frequency of SO (SOF), contractive duration of SO (SOD) and the pressure of common bile duct (CBDP) before and after drug administration were recorded and analyzed.
RESULTS: The levels of SOCA and SOBP decreased by 25.6% and 57.3% after 10 minutes of cimetidine treatment, and by 25.4% and 19.3% after 20 minutes of cimetidine treatment, respectively. There was significant difference before and after drug administration (P < 0.05). The levels of SOCA and SOBP also decreased after famotidine treatment, but there was no statistical difference. The other indexes had no obvious changes after drug administration.
CONCLUSION: Cimetidine at routine doses can decrease SOBP and SOCA, showing inhibitory effect on the motility of SO, while famotidine had no obvious effect on SO motility.
Key Words: Sphincter of Oddi; Famotidine; Cimetidine; Manometry; Motility
Zhang XB, Wu SD, Kong J, Wang W. Effects of famotidine and cimetidine on human sphincter of Oddi stress. Shijie Huaren Xiaohua Zazhi 2007;15(8):897-900
摘要
目的: 观察常规剂量的组胺H2受体阻滞剂法莫替丁、西咪替丁对Oddi括约肌(SO)运动功能的影响.
方法: 取胆道探查术后留有T型管患者20例, 随机分为法莫替丁组和西咪替丁组(n = 10), 测量用药前后的十二指肠压(DP)、SO基础压(SOBP)、收缩幅度(SOCA)、收缩频率(SOF)、收缩间期(SOD)及胆总管压(CBDP).
结果: 静推西咪替丁10 min后, SOCA及SOBP分别下降了25.6%及57.3%, 20 min后SOCA及SOBP分别下降了25.4%及19.3%, 给药前后自身对照统计学上有显著差别(P<0.05); 静脉推注法莫替丁后SOCA及SOBP有降低趋势, 但无统计学意义. 其他指标无明显变化.
结论: 常规剂量的西咪替丁可引起SOBP和SOCA降低, 对SO运动具抑制作用, 常规剂量的法莫替丁对SO压力无明显影响.
关键词: Oddi括约肌; 法莫替丁; 西咪替丁; 测压; 运动性
张小薄, 吴硕东, 孔静, 王伟. 法莫替丁及西咪替丁对Oddi括约肌压力变化的影响. 世界华人消化杂志 2007;15(8):897-900 ......
张小薄, 吴硕东, 孔静, 王伟, 中国医科大学盛京医院普外科 辽宁省沈阳市 110004
通讯作者: 吴硕东, 110004, 辽宁省沈阳市和平区三好街36号, 中国医科大学盛京医院普外科. wusd@cmu2h.com
电话: 024-83955058 传真: 024-83956291
收稿日期: 2006-10-26 接受日期: 2006-12-18
Effects of famotidine and cimetidine on human sphincter of Oddi pressure
Xiao-Bo Zhang, Shuo-Dong Wu, Jing Kong, Wei Wang
Xiao-Bo Zhang, Shuo-Dong Wu, Jing Kong, Wei Wang,Department of General Surgery, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China
Correspondence to:Shuo-Dong Wu, Department of General Surgery, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. wusd@cmu2h.com
Received:2006-10-26 Accepted:2006-12-18
Abstract
AIM:To assess the effects of famotidine and cimetidine at routine dosages on human sphincter of Oddi (SO) motility by choledochoscope manometry.
METHODS: A total of 20 patients with T tubes after cholecytectomy and choledochotomy were randomly divided into famotidine group and cimetidine group (n = 10). The pressure of duodenum (DP), basal pressure of SO (SOBP), contractive amplitude of SO (SOCA), contractive frequency of SO (SOF), contractive duration of SO (SOD) and the pressure of common bile duct (CBDP) before and after drug administration were recorded and analyzed.
RESULTS: The levels of SOCA and SOBP decreased by 25.6% and 57.3% after 10 minutes of cimetidine treatment, and by 25.4% and 19.3% after 20 minutes of cimetidine treatment, respectively. There was significant difference before and after drug administration (P < 0.05). The levels of SOCA and SOBP also decreased after famotidine treatment, but there was no statistical difference. The other indexes had no obvious changes after drug administration.
CONCLUSION: Cimetidine at routine doses can decrease SOBP and SOCA, showing inhibitory effect on the motility of SO, while famotidine had no obvious effect on SO motility.
Key Words: Sphincter of Oddi; Famotidine; Cimetidine; Manometry; Motility
Zhang XB, Wu SD, Kong J, Wang W. Effects of famotidine and cimetidine on human sphincter of Oddi stress. Shijie Huaren Xiaohua Zazhi 2007;15(8):897-900
摘要
目的: 观察常规剂量的组胺H2受体阻滞剂法莫替丁、西咪替丁对Oddi括约肌(SO)运动功能的影响.
方法: 取胆道探查术后留有T型管患者20例, 随机分为法莫替丁组和西咪替丁组(n = 10), 测量用药前后的十二指肠压(DP)、SO基础压(SOBP)、收缩幅度(SOCA)、收缩频率(SOF)、收缩间期(SOD)及胆总管压(CBDP).
结果: 静推西咪替丁10 min后, SOCA及SOBP分别下降了25.6%及57.3%, 20 min后SOCA及SOBP分别下降了25.4%及19.3%, 给药前后自身对照统计学上有显著差别(P<0.05); 静脉推注法莫替丁后SOCA及SOBP有降低趋势, 但无统计学意义. 其他指标无明显变化.
结论: 常规剂量的西咪替丁可引起SOBP和SOCA降低, 对SO运动具抑制作用, 常规剂量的法莫替丁对SO压力无明显影响.
关键词: Oddi括约肌; 法莫替丁; 西咪替丁; 测压; 运动性
张小薄, 吴硕东, 孔静, 王伟. 法莫替丁及西咪替丁对Oddi括约肌压力变化的影响. 世界华人消化杂志 2007;15(8):897-900 ......
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