Cyclin E在乳腺癌组织中的表达及其临床意义
乳腺癌；Cyclin,E；免疫组化；免疫功能,,],乳腺癌；Cyclin,E；免疫组化；免疫功能,CyclinE在乳腺癌组织中的表达及其临床意义,1资料与方法,2结果,3讨论,参考文献：
[摘要] 目的：探讨Cyclin E的表达在乳腺癌的发生、转移和复发中的作用。方法：通过免疫组化SP法检测Cyclin E在69例乳腺癌组织中的原位表达，并对肿瘤临床分期与其表达结果做相关性分析。结果：Cyclin E在乳腺癌中的表达率为47.8%，其与肿瘤临床分期及淋巴结转移呈正相关。Cyclin E在不同临床分期的乳腺癌组织中过表达率的差异具有显著性意义(χ2=8.154，P<0.05)。在乳腺癌患者淋巴结转移组，Cyclin E蛋白的阳性表达率为64.52%，远高于无淋巴结转移组的阳性率36.84%(χ2=5.231，P<0.05)。结论：Cyclin E的表达可预测乳腺癌患者淋巴结转移和复发，并可作为推断预后的重要指标之一。[关键词] 乳腺癌；Cyclin E；免疫组化；免疫功能
Expression of Cyclin E in Tissues of Breast Cancer
LI Yongyu，PENG Xiang
(1.Xiaotang Hospital of Foshan，Foshan,Guangdong 528222,China;
2.The Frist People's Hospital of Foshan, Foshan, Guangdong 528000,China)
Abstract：Objective To detect the expression level of Cyclin E protein in tissues of breast cance.Then to investigate the relationship between the expression of Cyclin E and the occurrence、metastasis and recurrence of breast cancer.Methods The expression level of Cyclin E protein in 69 breast cancer patients was detected by immunohistochemistry.Results The expression rate in 69 tissuses of breast cancer was 47.8%.The expression level of Cyclin E protein had a positive correlation with the clinical stage and metastasis.There was a significance difference with the expression level in different clinical stage patients(χ2=8.154 ......
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