卡维地洛；美托洛尔；高血压；代谢综合征____

卡维地洛对代谢综合征患者代谢指标的影响研究

http://www.100md.com 《实用医技杂志》 2007年第2期

卡维地洛；美托洛尔；高血压；代谢综合征,,],卡维地洛；美托洛尔；高血压；代谢综合征,1材料与方法,2结果,参考文献：

     [摘要] 目的：研究卡维地洛对代谢综合征患者血糖、血脂等代谢指标的影响。方法：入选60例符合代谢综合征诊断标准的轻度、中度高血压患者，并随机分为卡维地洛组和美托洛尔治疗组。在有效控制血压的同时，测量基础状态及接受治疗90天后的血糖、血胰岛素、及血脂水平等代谢指标。结果：用药前后，卡维地洛组胰岛素敏感性有所改善，美托洛尔组胰岛素敏感性无明显变化；用药后，美托洛尔组高密度脂蛋白(HDLC)水平下降，而卡维地洛组HDL水平变化不明显；卡维地洛组用药后载脂蛋白A(apoA)水平明显升高，而美托洛尔组无明显变化；其余代谢指标两组用药前后均未见明显变化。结论：卡维地洛对代谢综合征患者有效降压的同时，对其代谢指标无负面影响。

    [关键词] 卡维地洛；美托洛尔；高血压；代谢综合征

    The Effect of Carvedilol on Metabolic Parameters in Patients With Metabolic Syndrome

    ZHU Linqi,BAO Ling

    (A Military Area Oolity Fourth Cadres Rest Place of Beijing, Benjing 100036,China)

    Abstact： Objective To explore the effect of cavedilol treatment on metabolic parameters in metabolic syndrome. Methods A total of 60 patients with stage12 hypertension who fulfilled at least 3 of the metabolic syndrome criteria proposed by NCEPATPⅢ were included in this study. Patients were randomly assigned to receive daily treatment with carvedilol and metoprolol. The biochemical parameters and insulin sensitivity based on the HOMAIR model were evaluated at baseline and at the end of treatment. Results A significant decrease in insulin resistance (HOMAIR) in carvedilol group compared to the metoprolol group ( percent change -6.2±0.2 vs. +0.5±1.3, P<0.05). A significant decrease in HDL cholesterol levels occurred in the metoprolol group compared to the carvedilol group (percent change: -6.7±10.2 vs.-0.5±11.3, P<0.05). A significant increase in apolipoprotein A1 level was observed in the carvedilol group compared to the metoprolol group (percent change: +5.7±9.7 vs. -0.7±12.6, P<0.05). There were no significant differences between the two groups respect to other parameters. Conclusion It is concluded antihypertensive pressure without adversely affecting metabolic parameters. ......

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