【摘 要】 目的 探讨肝硬化患者血清转化生长因子β1 (TGF-β1 )和叶酸(FA)、维生素B12 (VB12 )水平的变化及临床意义。 方法 分别应用放免法和ELISA法对63例肝硬化患者进行了血清TGF-β1 、FA和VB12 水平的检测，并于35名正常健康人作对照。 结果 肝硬化患者血清TGF-β1 水平非常显著高于正常对照组(P<0.01)，而FA和VB12 水平显著低于正常对照组(P<0.01)。 结论 检测血清TGF-β1 、FA和VB12 水平对肝硬化的发生、发展以及疗效、预后均具有重要的临床价值。

    【关键词】 肝硬化;转化生长因子-β1 ;叶酸;维生素B12

    Clinical significance of determination of changes of TGF┐β1 /FA and VB12 levels in patients with hepatic cirrhosis

    ZHOU Yu-yang.

    (Siyang County People's Hospital，Jiangsu223700，China)

    【Abstract】 Objective To investigate the changes of serum TGF-β1 /FA and VB12 levels in patients with hepatic cir-rhosis and their significance.Methods Serum TGF-β1 level was measured with ELISA and FA/VB12 were detected with RIA in63patients with hepatic cirrhosis and35controls.Results The serum TGF-β1 level was higher and FA/VB12 levels were lower in the patients than those in the controls(P<0.01).Conclusion Determination of serum TGF-β1 /FA and VB12 levels is clinically useful in the management of patients with hepatic cirrhosis. ......