呼吸道感染；干扰素α2b；鼻腔；治疗结果____

重组干扰素α2b鼻腔给药治疗反复呼吸道感染效果

http://www.100md.com 《齐鲁医学杂志》 2007年第2期

呼吸道感染；干扰素α2b；鼻腔；治疗结果,,],呼吸道感染；干扰素α2b；鼻腔；治疗结果,1对象与方法,2结果,3讨论,[参考文献]

     [摘要] 目的探讨儿童反复呼吸道感染的有效治疗方法。方法 85例病儿随机分为治疗组和对照组，两组采用相同的抗感染及对症治疗，治疗组在体温正常3 d后给予重组干扰素α2b(rIFN2b)105U/d，双鼻腔内交替滴入，总疗程为15 d。结果治疗组病儿呼吸道感染的频率明显低于对照组(t=4.35,P<0.01)，感染后的主要症状轻，感染所持续的时间短于对照组(t=4.05,P<0.01)，且无明显副作用。结论 rIFN2b鼻腔内给药治疗反复呼吸道感染有明显效果。

    [关键词] 呼吸道感染；干扰素α2b；鼻腔；治疗结果

    EFFECTS OF RECOMBINANT INTERFERON α2b VIA INTRANASAL MEDICATION FOR CHILDREN WITH REPEATED RESPIRATORY TRACT INFECTIONZANG CHUANNONG, WANG YONGQIANG, XIAO CHUNGUANG, et al (Department of Pediatrics， Central Hospital of Wendeng, Wendeng 264400, China)

    [ABSTRACT]ObjectiveTo explore an effective therapy for children with repeated respiratory tract infection.Methods Eightyfive sick children were randomized to control group and treated group. The antibiotics and symptomatic therapy was the same for both groups, the only different was that for the treated group, recombinant interferon α2b (105 U/d) was given after the temperature returned to normal for three days. The course lasted for 15 days.ResultsIncidence of repeated respiratory tract infection in the treated group was lower than that in control (t=4.35,P<0.01). Symptoms of infection were milder and time lasting shorter (t=4.05,P<0.01). No obvious side effects were noted.ConclusionThe effect of intranasal medication of interferon α2b for children with repeated respiratory tract infection is significant. ......

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