大肠癌；血管内皮生长因子；Flk1；免疫组化_

大肠正常粘膜、腺瘤及癌组织中VEGF及其受体Flk1表达的意义

http://www.100md.com 《河北医药》 2007年第2期

大肠癌；血管内皮生长因子；Flk1；免疫组化,,大肠癌；血管内皮生长因子；Flk1；免疫组化,1资料与方法,2结果,3讨论,参考文献

     【摘要】目的探讨血管内皮生长因子(VEGF)及其受体Flk1在大肠癌发生中的作用。方法采用免疫组化技术检测正常大肠粘膜15例(NM组)、大肠腺瘤27例(Ad组)、大肠癌81例(CC组)中VEGF及其受体Flk1的表达。结果从NM到Ad到CC组VEGF及其受体Flk1的表达逐渐增高、增强组间均存在显著差异(P均<0.01)。结论 VEGF及其受体Flk1可作为大肠正常组织恶变的不良信号，检测VEGF及其受体Flk1可作为预测组织恶变的参考指标。

    【关键词】大肠癌；血管内皮生长因子；Flk1；免疫组化

    The significance of VEGF Flk1 expression in normal nucosa,adenoma and colorectal carcinoma

    SHI Yanhua,YE Hong,GUAN Lihua,et al. Chengde Medical College, Hebei, Chengde 067000

    【Abstract】 Objective To investigate the significance of VEGF and its receptor Flk1 expression in normal mucosa (NM),adenoma and colorectal carcinoma(CC). Methods SP immunohistochemical staining was used to examine expressions of VEGF, Flk1 among 15 cases of NM,27 cases of Ad and 81 cases of CC paraffinembedded specimens. Rank sum test was used to analyze the expressions of VEGF and Flk1.Results The expression of VEGF and Flk1 from NM to Ad to CC appeared an upward tendency. There were significant differences in VEGF and Flk1 expression between the two groups(P<0.01,P<0.01). Conclusions VEGF,Flk1 as bad signals in the occurrence of CC could be regarded as predictive factors of CC. ......

百拇医药网 http://www.100md.com/html/DirDu/2007/04/10/41/80/03.htm

您现在查看是摘要页，全文长 7159 字符。