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注射用头孢替坦钠的安全性再评价
http://www.100md.com 《中国抗生素杂志》 2007年第1期
注射用头孢替坦钠;,安全性评价;,静脉注射,,注射用头孢替坦钠;,安全性评价;,静脉注射,1材料,2实验方法与结果,3讨论,参考文献
     摘要: 目的 评价注射用头孢替坦钠的安全性。方法 将注射用头孢替坦钠配成适当浓度,观察豚鼠静脉注射后有无过敏反应(因头孢菌素类药物容易引起豚鼠中毒,所以增作大鼠过敏试验)、家兔静脉注射有无血管刺激性及热原反应、体外溶血试验中是否具有溶血和血球凝集作用。结果 大鼠静脉注射用头孢替坦钠无过敏反应,家兔静脉注射用头孢替坦钠无血管刺激性及热原反应,体外溶血试验无溶血和血球凝集作用。结论 注射用头孢替坦钠可供静脉注射试用给药。

    关键词: 注射用头孢替坦钠; 安全性评价; 静脉注射

    Safety evaluation of cefotetan sodium for injection

    He Xiaojing and Liu Yulan

    (The Second Affiliated Hospital of China Medical University, Shenyang 110004;School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016)

    ABSTRACT Objective To evaluate the safety of cefotetan sodium for injection. Methods Four experiments were used, including allergic test induced by cefotetan sodium in guinea pigs. Allergic test by cefotetan sodium in SD rats was added as well as haemolysis and blood cell agglutination test in vitro and stimulation test to blood vessel. Results No stimulations and pyrogen reactions were seen in rabbits, earrim auricular vein after given lansoprazole. Allergic reaction was not occurred in SD rats. Conclusion Cefotetan sodium is safe for intravenous injection. ......

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