http://www.100md.com
邱晓光，俞守义
非小细胞肺癌；循证医学；Meta分析；新辅助化疗；生存率；前瞻性研究,,非小细胞肺癌；循证医学；Meta分析；新辅助化疗；生存率；前瞻性研究,2结果,3讨论,【参考文献】
【摘要】 目的 探讨新辅助化疗对Ⅲ期非小细胞肺癌患者远期生存率的影响。方法 用循证医学的方法复习国内外文献，收集相关研究资料。根据获得的文献数据，分别对新辅助化疗和单纯手术治疗两种疗法的1年、3年和5年生存率情况进行Meta分析。结果 共检索出符合条件的国内外文献12篇。Meta分析显示两组间1年及3年生存率差异无显著性，而5年生存率差异有显著性。单独分析国内资料显示两组5年生存率差异无显著性。结论 尚不能确定两种治疗方式对Ⅲ期NSCLC患者远期生存率的影响，还需要进行多中心，更大样本量的前瞻性随机对照研究。
【关键词】 非小细胞肺癌；循证医学；Meta分析；新辅助化疗；生存率；前瞻性研究
Evidence based medical research of neoadjuvant chemotherapy on long-term survival rate of III stage non-small cell lung cancer
QIU Xiao-guang,YU Shou-yi.Public Health College, Nanfang Medical University, Guangzhou 510515, China
【Abstract】 Objective To study the influence of neoadjuvant chemotherapy to long-term survival rate of III stage non-small cell lung cancer (NSCLC).Methods Domestic and overseas literatures were reviewed with evidence based medical research method. Correlative research data were collected. 1, 3 and 5 years survival rates of neoadjuvant chemotherapy group and surgery alone group were meta analyzed according the acquired data. Results Total 12 domestic and overseas literatures consistent with the conditions were detected. Meta-analysis results indicated that 1 and 3 years survival rates were not significantly different but 5 years survival rates were significantly different between the two groups. However, 5 years survival rates were not significantly different between the two groups when the domestic literatures were meta analyzed alone. Conclusion The influences of neoadjuvant chemotherapy and surgery alone to long-term survival rates of III stage NSCLC patients were still not definite. We still need more multicenter and large sample prospective random control studies.
【关键词】 非小细胞肺癌；循证医学；Meta分析；新辅助化疗；生存率；前瞻性研究
Evidence based medical research of neoadjuvant chemotherapy on long-term survival rate of III stage non-small cell lung cancer
QIU Xiao-guang,YU Shou-yi.Public Health College, Nanfang Medical University, Guangzhou 510515, China
【Abstract】 Objective To study the influence of neoadjuvant chemotherapy to long-term survival rate of III stage non-small cell lung cancer (NSCLC).Methods Domestic and overseas literatures were reviewed with evidence based medical research method. Correlative research data were collected. 1, 3 and 5 years survival rates of neoadjuvant chemotherapy group and surgery alone group were meta analyzed according the acquired data. Results Total 12 domestic and overseas literatures consistent with the conditions were detected. Meta-analysis results indicated that 1 and 3 years survival rates were not significantly different but 5 years survival rates were significantly different between the two groups. However, 5 years survival rates were not significantly different between the two groups when the domestic literatures were meta analyzed alone. Conclusion The influences of neoadjuvant chemotherapy and surgery alone to long-term survival rates of III stage NSCLC patients were still not definite. We still need more multicenter and large sample prospective random control studies.