小柴胡汤诱导内异症异位内膜细胞凋亡的研究
小柴胡汤;,内异症;,异位内膜细胞凋亡,,小柴胡汤;,内异症;,异位内膜细胞凋亡,1材料,2方法,3结果,4讨论,参考文献:
摘要:目的探讨小柴胡汤对内异症大鼠异位内膜细胞凋亡的影响。方法建立大鼠内异症模型,采用透射电镜技术及免疫组化方法,观察小柴胡汤对异位内膜细胞形态结构和Fas及Caspase-3蛋白表达的影响。结果中、高剂量小柴胡汤(10,15 g·kg-1·d-1)治疗后,异位内膜有较多腺上皮细胞出现凋亡的特征,表现为细胞体积变小,核固缩,胞浆和核染色质凝集,密度增高,细胞间凋亡小体,同时间质细胞中可见一些坏死细胞;异位内膜Fas蛋白、Caspase-3蛋白的表达水平明显高于其在位内膜。结论 小柴胡汤可通过上调Fas蛋白的表达,诱导异位内膜细胞的凋亡。关键词:小柴胡汤; 内异症; 异位内膜细胞凋亡
The Study of XiaoChaiHu Decoction on Ectopic Endometrium Cell Apoptosis
ZHENG Hui, ZUO Liandong
(Medical College of Jinan University, Guangzhou 510632, China)
Abstract:ObjectiveTo explore the effect of XiaoChaiHu Decoction on ectopic endometrium cell apoptosis in rats. MethodsUsing the rat model, ectopic endometrium was evaluated by electron microscope. Fas and Caspase-3 protein expression in the endometrium and endometriotic tissue were observed by immunohistochemical method.ResultsThe glandular cell in the endometrial implant after therapy with middle or high-dose of (10 ......
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