Effect of greenª²light photoselective vaporization on vascular endothelial function of patients with benign prostatic hyperplasia and its safety during perioperative period

    LUO Xiangª²Ning, WANG He, YANG Bo, LIU Heª²Liang, LI Xin, QIN Rongª²Liang, YUAN Jianª²Lin, ZHAI Zhenª²Bo, MA Jianª²Jun

    Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi¬ðan 710033, China

    ¡¾Abstract¡¿ AIM: To investigate the relationship between greenª²light photoselective vaporization (PVP) and the stroke of coronary heart disease (CHD) and access the safety of PVP for benign prostatic hyperplasia (BPH) combined with CHD during perioperative period. METHODS: Seventyª²two patients underwent surgical treatment: openª²operation (n=34), PVP (n=38). All 72 patients were divided into 2 groups according to whether BPH was combined with CHD or not(CHD group and nonª²CHD group). The serum level of ETª²1 was measured by ELISA before and after treatment,respectively. RESULTS: The levels of ETª²1 in CHD groups[OP group vs PVP group: (83.19¡À12.83) vs (85.98¡À10.19) ng/L] before operation showed no significant difference(t£½0.777,P>0.05);One day after operation, the level of serum ETª²1 of OP group[(123.01¡À25.98) ng/L] was significantly higher than that of PVP group[(92.74¡À10.40) ng/L](t£½2.823, P<0.01), and 2d after operation, the level of serum ETª²1 of OP group[(114.1¡À28.22) ng/L] was still significantly higher than that of PVP group[(90.12¡À10.22) ng/L] (t£½4.678, P<0.01). The levels of ETª²1 of nonª²CHD group [OP group vs PVP groups: (49.74¡À9.23) vs (48.10¡À9.10) ng/L] before operation showed no significant difference(t£½0.478,P>0.05); 1d after operation, the level of serum ETª²1 of OP group[(68.67¡À12.55) ng/L] was significantly higher than that of PVP group[(53.89¡À9.70) ng/L](t=4.370, P<0.01), and 2 d after operation, the level of serum ETª²1 of OP group[(114.1¡À28.22) ng/L] was still significantly higher than that of PVP group[(90.12¡À10.22) ng/L] (t£½2.614,P<0.05). CONCLUSION: There is a significantly damaged vascular endothelial function after OP in BPH patients, especially in BPH patients complicated with CHD.PVP is a kind of safe operation to BPH patients, especially those combined with CHD. ......