流行性感冒病毒鸡胚高产株的遗传特性分析
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中国疾病预防控制中心病毒病预防控制所 北京100052 董婕；张立国；陈爱君；吴昆昱；孙梅生；张智清
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中国疾病预防控制中心病毒病预防控制所 北京100052 董婕；张立国；陈爱君；吴昆昱；孙梅生；张智清
关键词：流行性感冒病毒；高产毒株；基因突变
摘要：Influenza virus strain A/PR/8/34(H1N1)acquired a high-yielding property after serial passages in fertilized eggsSix internal RNA segments of the high-yielding strain were sequenced from their cloned cDNAs and compared with the corresponding original sequences in the prime A/PR/8/34(H1N1)strainNinety-three point mutations were found accumulated in six genes(PB2,PB1,PA,NP,M,and NS),which lead to 27 amino acid changesA significant low mutatio...
中国疾病预防控制中心病毒病预防控制所 北京100052 董婕；张立国；陈爱君；吴昆昱；孙梅生；张智清
关键词：流行性感冒病毒；高产毒株；基因突变
摘要：Influenza virus strain A/PR/8/34(H1N1)acquired a high-yielding property after serial passages in fertilized eggsSix internal RNA segments of the high-yielding strain were sequenced from their cloned cDNAs and compared with the corresponding original sequences in the prime A/PR/8/34(H1N1)strainNinety-three point mutations were found accumulated in six genes(PB2,PB1,PA,NP,M,and NS),which lead to 27 amino acid changesA significant low mutatio...
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