姜黄素—PLGA纳米粒温敏原位凝胶的制备及其在兔眼房水中的药动学研究(4)
[ 3 ] MOSIENIAK G，ADAMOWICZ M，ALSTER O，et al. Curcumin induces permanent growth arrest of human colon cancer cells：link between senescence and autophagy [J]. Mech Ageing Dev，2012，133(6)：444-455.
[ 4 ] PESCOSOLIDO N，GIANNOTTI R，PLATEROTI AM，et al. Curcumin：therapeutical potential in ophthalmology [J]. Planta Med，2014，80(4)：249-254.
[ 5 ] SULAIMAN RS，BASAVARAJAPPA HD， CORSON TW. Natural product inhibitors of ocular angiogenesis[J]. Exp Eye Res，2014，129(8)：161-171.
, 百拇医药
[ 6 ] GRANATA G，PATERNITI I，GERACI C，et al. Potential eye drop based on a calixarene nanoassembly for curcumin delivery：enhanced drug solubility，stability，and anti-inflammatory effect[J]. Mol Pharm，2017，14(5)：1610- 1622.
[ 7 ] LU CW，HAO JL，YAO L，et al. Efficacy of curcumin in inducing apoptosis and inhibiting the expression of VEGF in human pterygium fibroblasts[J]. Int J Mol Med，2017，39(5)：1149-1154.
[ 8 ] PATEL N，NAKRANI H，RAVAL M，et al. Development of loteprednol etabonate-loaded cationic nanoemulsified in-situ ophthalmic gel for sustained delivery and enhanced ocular bioavailability[J]. Drug Deliv，2016，23(9)：3712- 3723.
, http://www.100md.com
[ 9 ] PATEL N，THAKKAR V，METALIA V，et al. Formulation and development of ophthalmic in situ gel for the treatment ocular inflammation and infection using application of quality by design concept[J]. Drug Dev Ind Pharm，2016，42(9)：1406-1423.
[10] 朱志新，钱颖，曹青日，等.姜黄素-PLGA纳米粒的制备与药效学评价[J].中成药，2011，33(5)：776-779.
[11] 郑毅，郑施施，王增寿.姜黄素-PLGA纳米粒提高口服给药生物利用度的研究[J].中国现代应用药学，2014，31(6)：717-721.
[12] 郝吉福，赵雪梅，王建筑，等.温度敏感型盐酸小檗碱眼用原位凝胶的制备研究[J].中草药，2010，41(4)：550-555.
, http://www.100md.com
[13] BOZDAG S，GUMUS K，GUMUS O，et al. Formulation and in vitro evaluation of cysteamine hydrochloride viscous solutions for the treatment of corneal cystinosis[J]. Eur J Pharm Biopharm，2008，70(1)：260-269.
[14] PAI A，EL SHAFEI MM，MOHAMMED OA，et al. Current concepts in intravitreal drug therapy for diabetic retinopathy[J]. Saudi J Ophthalmol，2010，24(4)：143-149.
[15] LIAO PL，LIN CH，LI CH，et al. Anti-inflammatory properties of shikonin contribute to improved early-stage diabetic retinopathy[J]. Sci Rep，2017.DOI：10.1038/srep 44985.
, 百拇医药
[16] LOU J，HU W，TIAN R，et al. Optimization and evaluation of a thermoresponsive ophthalmic in situ gel containing curcumin-loaded albumin nanoparticles[J]. Int J Nanomedicine，2014.DOI：10.2147/IJN.S60270.ecollection2014.
[17] DANHIER F，ANSORENA E，SILVA JM，et al. PLGA- based nanoparticles：an overview of biomedical applications[J]. J Control Release，2012，161(2)：505-522.
(收稿日期：2017-07-29 修回日期：2018-01-05)
(編辑：刘明伟), 百拇医药(李林芝 刘梅 常颖)
[ 4 ] PESCOSOLIDO N，GIANNOTTI R，PLATEROTI AM，et al. Curcumin：therapeutical potential in ophthalmology [J]. Planta Med，2014，80(4)：249-254.
[ 5 ] SULAIMAN RS，BASAVARAJAPPA HD， CORSON TW. Natural product inhibitors of ocular angiogenesis[J]. Exp Eye Res，2014，129(8)：161-171.
, 百拇医药
[ 6 ] GRANATA G，PATERNITI I，GERACI C，et al. Potential eye drop based on a calixarene nanoassembly for curcumin delivery：enhanced drug solubility，stability，and anti-inflammatory effect[J]. Mol Pharm，2017，14(5)：1610- 1622.
[ 7 ] LU CW，HAO JL，YAO L，et al. Efficacy of curcumin in inducing apoptosis and inhibiting the expression of VEGF in human pterygium fibroblasts[J]. Int J Mol Med，2017，39(5)：1149-1154.
[ 8 ] PATEL N，NAKRANI H，RAVAL M，et al. Development of loteprednol etabonate-loaded cationic nanoemulsified in-situ ophthalmic gel for sustained delivery and enhanced ocular bioavailability[J]. Drug Deliv，2016，23(9)：3712- 3723.
, http://www.100md.com
[ 9 ] PATEL N，THAKKAR V，METALIA V，et al. Formulation and development of ophthalmic in situ gel for the treatment ocular inflammation and infection using application of quality by design concept[J]. Drug Dev Ind Pharm，2016，42(9)：1406-1423.
[10] 朱志新，钱颖，曹青日，等.姜黄素-PLGA纳米粒的制备与药效学评价[J].中成药，2011，33(5)：776-779.
[11] 郑毅，郑施施，王增寿.姜黄素-PLGA纳米粒提高口服给药生物利用度的研究[J].中国现代应用药学，2014，31(6)：717-721.
[12] 郝吉福，赵雪梅，王建筑，等.温度敏感型盐酸小檗碱眼用原位凝胶的制备研究[J].中草药，2010，41(4)：550-555.
, http://www.100md.com
[13] BOZDAG S，GUMUS K，GUMUS O，et al. Formulation and in vitro evaluation of cysteamine hydrochloride viscous solutions for the treatment of corneal cystinosis[J]. Eur J Pharm Biopharm，2008，70(1)：260-269.
[14] PAI A，EL SHAFEI MM，MOHAMMED OA，et al. Current concepts in intravitreal drug therapy for diabetic retinopathy[J]. Saudi J Ophthalmol，2010，24(4)：143-149.
[15] LIAO PL，LIN CH，LI CH，et al. Anti-inflammatory properties of shikonin contribute to improved early-stage diabetic retinopathy[J]. Sci Rep，2017.DOI：10.1038/srep 44985.
, 百拇医药
[16] LOU J，HU W，TIAN R，et al. Optimization and evaluation of a thermoresponsive ophthalmic in situ gel containing curcumin-loaded albumin nanoparticles[J]. Int J Nanomedicine，2014.DOI：10.2147/IJN.S60270.ecollection2014.
[17] DANHIER F，ANSORENA E，SILVA JM，et al. PLGA- based nanoparticles：an overview of biomedical applications[J]. J Control Release，2012，161(2)：505-522.
(收稿日期：2017-07-29 修回日期：2018-01-05)
(編辑：刘明伟), 百拇医药(李林芝 刘梅 常颖)