SREBPs天然小分子抑制剂的药理学研究进展(5)
[20] DING L，LI J，SONG B，et al. Andrographolide prevents high-fat diet-induced obesity in C57BL/6 mice by suppressing the SREBP pathway[J]. J Pharmacol Exp Ther，2014，351(2)：474-483.
[21] KWON HH，YOON JY，PARK SY，et al. Activity-guided purification identifies lupeol，a pentacyclic triterpene，as a therapeutic agent multiple pathogenic factors of acne[J]. J Invest Dermatol，2015，135(6)：1491-1500.
[22] WANG C，DUAN X，SUN X，et al. Protective effects of glycyrrhizic acid from edible botanical glycyrrhiza glabra against non-alcoholic steatohepatitis in mice[J]. Food Funct，2016，7(9)：3716-3723.
, http://www.100md.com
[23] LIU W，FURUTA E，SHINDO K，et al. Cacalol，a natural sesquiterpene，induces apoptosis in breast cancer cells by modulating AKT-SREBP-FAS signaling pathway[J]. Breast Cancer Res Treat，2011，128(1)：57-68.
[24] LEE I，KIM J，RYOO I，et al. Lanostane triterpenes from Ganoderma lucidum suppress the adipogenesis in 3T3-L1 cells through down-regulation of SREBP-1c[J]. Bioorg Med Chem Lett，2010，20(18)：5577-5581.
[25] JANG J，JUNG Y，SEO SJ，et al. Berberine activates AMPK to suppress proteolytic processing，nuclear translocation and target DNA binding of SREBP-1c in 3T3-L1 adipocytes[J]. Mol Med Rep，2017，15(6)：4139-4147.
, 百拇医药
[26] LI Y，ZHAO X，FENG X，et al. Berberine alleviates olanzapine-induced adipogenesis via the AMPK alpha-SREBP pathway in 3T3-L1 cells[J]. Int J Mol Sci，2016，17(11)：e1865.
[27] QUAN HY，KIM DY，CHUNG SH. Caffeine attenuates lipid accumulation via activation of AMP-activated protein kinase signaling pathway in HepG2 cells[J]. BMB Rep，2013，46(4)：207-212.
[28] SONG CY，SHI J，ZENG X，et al. Sophocarpine alleviates hepatocyte steatosis through activating AMPK signaling pathway[J]. Toxicol in Vitro，2013，27(3)：1065-1071.
, http://www.100md.com
[29] VARSHNEY S，SHANKAR K，BEG M，et al. Rohitukine inhibits in vitro adipogenesis arresting mitotic clonal expansion and improves dyslipidemia in vivo[J]. J Lipid Res，2014，55(6)：1019-1032.
[30] MIYATA S，INOUE J，SHIMIZU M，et al. Xanthohumol improves diet-induced obesity and fatty liver by suppressing sterol regulatory element-binding protein(SREBP)activation[J]. J Biol Chem，2015，290(33)：20565-20579.
[31] ZHENG ZG，ZHOU YP，ZHANG X，et al. Anhydroicaritin improves diet-induced obesity and hyperlipidemia and alleviates insulin resistance by suppressing SREBPs activation[J]. Biochem Pharmacol，2016，122：42-61.
[32] LIM W，YANG C，BAZER FW，et al. Luteolin inhibits proliferation and induces apoptosis of human placental choriocarcinoma cells by blocking the PI3K/AKT pathway and regulating sterol regulatory element binding protein activity[J]. Biol Reprod，2016，95(4)：82., 百拇医药(谢治深 赵振彪 张振强 王辉)
[21] KWON HH，YOON JY，PARK SY，et al. Activity-guided purification identifies lupeol，a pentacyclic triterpene，as a therapeutic agent multiple pathogenic factors of acne[J]. J Invest Dermatol，2015，135(6)：1491-1500.
[22] WANG C，DUAN X，SUN X，et al. Protective effects of glycyrrhizic acid from edible botanical glycyrrhiza glabra against non-alcoholic steatohepatitis in mice[J]. Food Funct，2016，7(9)：3716-3723.
, http://www.100md.com
[23] LIU W，FURUTA E，SHINDO K，et al. Cacalol，a natural sesquiterpene，induces apoptosis in breast cancer cells by modulating AKT-SREBP-FAS signaling pathway[J]. Breast Cancer Res Treat，2011，128(1)：57-68.
[24] LEE I，KIM J，RYOO I，et al. Lanostane triterpenes from Ganoderma lucidum suppress the adipogenesis in 3T3-L1 cells through down-regulation of SREBP-1c[J]. Bioorg Med Chem Lett，2010，20(18)：5577-5581.
[25] JANG J，JUNG Y，SEO SJ，et al. Berberine activates AMPK to suppress proteolytic processing，nuclear translocation and target DNA binding of SREBP-1c in 3T3-L1 adipocytes[J]. Mol Med Rep，2017，15(6)：4139-4147.
, 百拇医药
[26] LI Y，ZHAO X，FENG X，et al. Berberine alleviates olanzapine-induced adipogenesis via the AMPK alpha-SREBP pathway in 3T3-L1 cells[J]. Int J Mol Sci，2016，17(11)：e1865.
[27] QUAN HY，KIM DY，CHUNG SH. Caffeine attenuates lipid accumulation via activation of AMP-activated protein kinase signaling pathway in HepG2 cells[J]. BMB Rep，2013，46(4)：207-212.
[28] SONG CY，SHI J，ZENG X，et al. Sophocarpine alleviates hepatocyte steatosis through activating AMPK signaling pathway[J]. Toxicol in Vitro，2013，27(3)：1065-1071.
, http://www.100md.com
[29] VARSHNEY S，SHANKAR K，BEG M，et al. Rohitukine inhibits in vitro adipogenesis arresting mitotic clonal expansion and improves dyslipidemia in vivo[J]. J Lipid Res，2014，55(6)：1019-1032.
[30] MIYATA S，INOUE J，SHIMIZU M，et al. Xanthohumol improves diet-induced obesity and fatty liver by suppressing sterol regulatory element-binding protein(SREBP)activation[J]. J Biol Chem，2015，290(33)：20565-20579.
[31] ZHENG ZG，ZHOU YP，ZHANG X，et al. Anhydroicaritin improves diet-induced obesity and hyperlipidemia and alleviates insulin resistance by suppressing SREBPs activation[J]. Biochem Pharmacol，2016，122：42-61.
[32] LIM W，YANG C，BAZER FW，et al. Luteolin inhibits proliferation and induces apoptosis of human placental choriocarcinoma cells by blocking the PI3K/AKT pathway and regulating sterol regulatory element binding protein activity[J]. Biol Reprod，2016，95(4)：82., 百拇医药(谢治深 赵振彪 张振强 王辉)