丹皮酚对强直性脊柱炎模型小鼠Wnt和BMP/Smad信号转导通路的影响(4)
[ 3 ] LORIES RJ，HAROON N. Bone formation in axial spondyloarthritis[J]. Best Pract Res Clin Rheumatol，2014，28(5)：765-777.
[ 4 ] YANG Y，DAI M. Expression of PADI4 in patients with ankylosing spondylitis and its role in mediating the effects of TNF-α on the proliferation and osteogenic differentiation of human mesenchymal stem cells[J]. Int J Mol Med，2015，36(2)：565-570.
[ 5 ] BLEIL J，SIEPER J，MAIER R，et al. Cartilage in facet joints of patients with ankylosing spondylitis (AS) shows signs of cartilage degeneration rather than chondrocyte hypertrophy：implications for joint remodeling in AS[J]. Arthritis Res Ther，2015.DOI：10.1186/s13075-015-0675-5.
, 百拇医药
[ 6 ] RANGANATHAN V，GRACEY E，BROWN MA，et al. Pathogenesis of ankylosing spondylitis-recent advances and future directions[J]. Nat Rev Rheumatol，2017，13(6)：359-367.
[ 7 ] BROWN MA，KENNA T，WORDSWORTH BP. Genetics of ankylosing spondylitis-insights into pathogenesis[J]. Nat Rev Rheumatol，2016，12(2)：81-91.
[ 8 ] ASHE HL. Modulation of BMP signalling by integrins[J]. Biochem Soc T，2016，44(5)：1465-1473.
, 百拇医药
[ 9 ] ALTONEN K，HEINONEN A，JOENSUU J，et al. Effectiveness and drug survival of TNF-inhibitors in the treatment of psoriatic arthritis：a prospective cohort study[J]. Semin Arthritis Rheu，2017，46(6)：732-739.
[10] 耿帅，赵育林，曾凯，等.丹皮酚的研究进展[J].中国新药与临床杂志，2016，38(5)：310-313.
[11] TSAI CY，KAPOOR M，HUANG YP，et al. Synthesis and evaluation of aminothiazole-paeonol derivatives as potential anticancer agents[J]. Molecules，2016，21(2)：145- 154.
, http://www.100md.com
[12] 吳琪，周晓红，杨德才，等.徐长卿-二妙散-三藤方对蛋白聚糖诱导关节炎模型小鼠血清中TNF-α和DKK-1含量的影响[J].中国药房，2017，28(31)：4369-4372.
[13] 童文文，李甲，徐卫东.蛋白聚糖诱导小鼠关节炎模型的研究进展[J].第二军医大学学报，2015，36(5)：530-535.
[14] HE GX，ShI Y，LIM J，et al. Differential involvement of Wnt signaling in Bmp regulation of cancellous versus periosteal bone growth[J]. Bone Res，2017.DOI：10.1038/boneres.
[15] DEES C，SCHLOTTMANN I，FUNKE R，et al. The Wnt antagonists DKK1 and SFRP1 are downregulated by promoter hypermethylation in systemic sclerosis[J]. Ann Rheum Dis，2014，73(6)：1232-1239.
[16] DONG M，YU DS，DURAIPANDIYAN V，et al. The protective effect of chrysanthemum indicum extract against ankylosing spondylitis in mouse models[J]. Biomed Res Int，2007.DOI：10.1155/2017/8206281.
(收稿日期：2017-12-13 修回日期：2018-03-20)
(编辑：林 静), http://www.100md.com(吴琪 吴倩 周晓红 吴玲慧)
[ 4 ] YANG Y，DAI M. Expression of PADI4 in patients with ankylosing spondylitis and its role in mediating the effects of TNF-α on the proliferation and osteogenic differentiation of human mesenchymal stem cells[J]. Int J Mol Med，2015，36(2)：565-570.
[ 5 ] BLEIL J，SIEPER J，MAIER R，et al. Cartilage in facet joints of patients with ankylosing spondylitis (AS) shows signs of cartilage degeneration rather than chondrocyte hypertrophy：implications for joint remodeling in AS[J]. Arthritis Res Ther，2015.DOI：10.1186/s13075-015-0675-5.
, 百拇医药
[ 6 ] RANGANATHAN V，GRACEY E，BROWN MA，et al. Pathogenesis of ankylosing spondylitis-recent advances and future directions[J]. Nat Rev Rheumatol，2017，13(6)：359-367.
[ 7 ] BROWN MA，KENNA T，WORDSWORTH BP. Genetics of ankylosing spondylitis-insights into pathogenesis[J]. Nat Rev Rheumatol，2016，12(2)：81-91.
[ 8 ] ASHE HL. Modulation of BMP signalling by integrins[J]. Biochem Soc T，2016，44(5)：1465-1473.
, 百拇医药
[ 9 ] ALTONEN K，HEINONEN A，JOENSUU J，et al. Effectiveness and drug survival of TNF-inhibitors in the treatment of psoriatic arthritis：a prospective cohort study[J]. Semin Arthritis Rheu，2017，46(6)：732-739.
[10] 耿帅，赵育林，曾凯，等.丹皮酚的研究进展[J].中国新药与临床杂志，2016，38(5)：310-313.
[11] TSAI CY，KAPOOR M，HUANG YP，et al. Synthesis and evaluation of aminothiazole-paeonol derivatives as potential anticancer agents[J]. Molecules，2016，21(2)：145- 154.
, http://www.100md.com
[12] 吳琪，周晓红，杨德才，等.徐长卿-二妙散-三藤方对蛋白聚糖诱导关节炎模型小鼠血清中TNF-α和DKK-1含量的影响[J].中国药房，2017，28(31)：4369-4372.
[13] 童文文，李甲，徐卫东.蛋白聚糖诱导小鼠关节炎模型的研究进展[J].第二军医大学学报，2015，36(5)：530-535.
[14] HE GX，ShI Y，LIM J，et al. Differential involvement of Wnt signaling in Bmp regulation of cancellous versus periosteal bone growth[J]. Bone Res，2017.DOI：10.1038/boneres.
[15] DEES C，SCHLOTTMANN I，FUNKE R，et al. The Wnt antagonists DKK1 and SFRP1 are downregulated by promoter hypermethylation in systemic sclerosis[J]. Ann Rheum Dis，2014，73(6)：1232-1239.
[16] DONG M，YU DS，DURAIPANDIYAN V，et al. The protective effect of chrysanthemum indicum extract against ankylosing spondylitis in mouse models[J]. Biomed Res Int，2007.DOI：10.1155/2017/8206281.
(收稿日期：2017-12-13 修回日期：2018-03-20)
(编辑：林 静), http://www.100md.com(吴琪 吴倩 周晓红 吴玲慧)