【摘 要】目的：了解2016-2018年本院肠杆菌属分布情况及部分耐药基因分型。方法：利用WHONET5.6软件分析耐药率变化。针对产ESBLs酶菌株进行CTX-M-1、SHV型耐药基因分型。结果：2016-2018年期间共得到肠杆菌属124株;大多数菌株来自神经外科(19%)，标本类型主要为痰(56%);肠杆菌属对青霉素类、头孢菌素类、单环β-内酰胺类抗菌素均存在较高耐药率(>20%)，对复方新诺明的耐药率明显呈上升趋势。有46(37.1%)株对ESBLs耐药菌株，主要为CTX-M-15型(21.7%)。结论：建议通过更多的研究建立一套完整的基因耐药监测体系。

    【关键词】肠杆菌属;ESBLs;耐药;CTX-M-1;SHV

    Abstract：Objective To understand the distribution of Enterobacter and the types of drug resistance genes in the isolated specimens of our hospital from 2016 to 2018. Methods：The change of drug resistance rate was analyzed by WHONET5.6 software. CTX-M-1 and SHV-type genotyping were performed on strains producing ESBLs.Results： A total of 124 strains of Enterobacter were obtained during 2016-2018;Most of the strains were from neurosurgery(19%).The type of specimen was mainly sputum (56%); Enterobacteriaceae have high resistance rate to penicillins ......