观察丹参酮ⅡA联合纳络酮和胞二磷胆碱治疗新生儿缺血缺氧性脑病的疗效(1)
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【摘要】目的 探讨丹参酮ⅡA联合纳络酮和胞二磷胆碱治疗新生儿缺血缺氧性脑病(HIE)的疗效。方法 将124例HIE患儿随机分为两组。治疗组62例, 对照组62例。对照组采用三维持、三对症等综合治疗，治疗组在对照组的基础上给予丹参酮ⅡA剂量为每次0.1mg/kg，加入10%葡萄糖注射液20ml中静脉点滴；纳洛酮初始剂量为每次0.2mg/kg，加入10%葡萄糖注射液20 ml中静脉点滴，共3天；3天后，静脉滴注每次0.15mg/kg，加入10%葡萄糖注射液20 ml中静脉点滴，每日1次，连用7 天，胞二磷胆碱剂量为每次0.1mg/kg，加入10%葡萄糖注射液20ml中静脉点滴。圴10天为1个疗程。结果 治疗组与对照组临床疗效比较，治疗组总有效率为95.16%，明显高于对照组的67.74%(X2=15.43 、P<0.01)；治疗组显效率为62.90%，明显高于对照组的22.58%(X2=20.60 、P<0 .01) ；治疗组在意识障碍消失时间上少于对照组(P<0.01)，在控制惊厥、恢复原始反射时间上两组差异有高度显著性(P<0.01)，在呼吸衰竭、肌张力减弱消失时间上两组差异有高度显著性(P<0.01)， 结论 丹参酮ⅡA联合纳络酮和胞二磷胆碱治疗HIE可明显改善患儿的临床症状并显著提高疗效，有利于提高患儿成活率，有利于患儿及早康复，且用药安全，未发现毒副作用，值得推广。
【关键词】丹参酮ⅡA 纳络酮 胞二磷胆碱 新生儿 缺血缺氧性脑病
中图分类号：R722.1〓〓〓〓〓〓文献标识码：A〓〓〓〓〓〓文章编号：1005-0515(2011)11-018-03
Observe the result of Tanshinone Ⅱ A with Naloxone and Citicoline on neonate hypoxie-ischemic encephalopathy
WEN YanHua ZONG ChuanHui
(Centralhospital of Caodian Town , yangzhou ,Jiangsu ,China)
【Abstract】Objective Effects of Tanshinone Ⅱ A with Naloxone and Citicoline on neonate hypoxie-ischemic encephalopathy(HIE) . Methods One hundred twenty cases of HIE were divided randomly into 2 groups . The treatment group 62 cases ,the control group 62 cases . The control group 62 cases used three maintenance therapys、three allopathic,etc; the treatment group was treated with tanshinon ⅡAsilate 0.1mg/kg of once, add 10% glucose injection 20 ml intravenous drip on the basis of control group therapy method ; predose of Naloxone 0.2mg/kg each time, add 10% glucose injection 20 ml intravenous drip, for a course of 3days;after 3 days , 0.15mg/kg each time , add 10% glucose injection 20 ml intravenous drip,qd, constant used 7 days, Citicoline 0.1mg/kg each time , add 10% glucose injection 20 ml intravenous drip. for a course of 10days every time.Results Comparison of the clinical efficacy of the treatment group and the control group , in the treatment group the rate of improvement was 95.16%,that rate of marked improvement was 62.90%,in the control group was 67.74%(X2=15.43 、P<0 .01) and 22.58%(X2=20.60 、P<0 .01)).the fade time of the disturbance of consciousness under the control group(P<0.01),at the time of controlled convulsions、resume Primitive reflex、respiratory failure and hypomyotonia, There were significant differences between the two groups(P<0 ......
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