肝癌根治性手术联合肝动脉\门静脉化疗使用乌司他丁的效果观察(1)
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2010年10月1日
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[摘要]目的观察探讨原发性肝癌病人术后化疗使用乌司他丁对肝功能及机体免疫功能的影响。方法 收集2007年至2009年在中山大学附属第二医院行肝癌手术治疗后行联合肝动脉、门静脉化疗的病人共60例,分为乌司他丁组( n=30) 和对照组( n=30) , 乌司他丁组化疗时按5000 U/kg连续使用乌司他丁7 天, 对照组以等量生理盐水, 检测和分析化疗前、后不同时期肝功能和免疫机能的变化。结果 化疗4 天后ALT、AST、TBIL 明显升高( P<0.05) , 乌司他丁治疗组ALT、AST、TBIL 明显低于对照组( P<0.01) ; 乌司他丁组与对照组间CD4+细胞计数及CD4+/CD8+比值有显著性差异( P<0.05) , 两组患者的CD3+、CD4+细胞计数及CD4+/CD8+比值均在化疗4 天后明显降低( P<0.05), 7 天后回升; 但乌司他丁治疗组波动幅度较小。结论乌司他丁在肝癌术后门静脉化疗具有良好的肝功能保护作用, 能增强化疗时的免疫功能。
[关键词]肝癌; 化疗; 乌司他丁; 肝功能; 免疫功能
[中图分类号] R735.7[文献标识码]A [文章编号] 1005-0515(2010)-10-020-02
Effects of ulinastatin on immune and liver function in combination of hepatic artery and portal
vein chemotherapy after resection of hepatocellular carcinoma
[Abstract]ObjectiveTo observe the effects of ulinastatin(UTI)on immune and liver function in portal vein chemotherapy after resection of hepatocellular carcinoma(HCC). Methods60 HCC patients after surgery from 2007 to 2009 in the Second Hospital of Sun Yat-San Univercity with combination of hepatic artery and portal vein chemotherapy,which were divided into UTI group (n = 30) and control group (n = 30), The UTI group chemotherapy use Ulinastatin 5000 U / kg up to continuous 7 days, equal dosage saline for control group, detection and analysis of chemotherapy before and after different periods of liver function and immune function changes. Results4 days after chemotherapy ,the level ofALT, AST, TBIL significantly rose(P <0.05). the level ofALT, AST, TBIL of UTI group were significantly lower than control group (P <0.01); CD4 + cell count and CD4 + / CD8 + ratio was significantly differentbetween UTI group and control group (P <0.05), count of CD3 +, CD4 + cell and CD4 + / CD8 + ratio were significantly decreased 4 days after chemotherapy( P<0.05),but recover after 7 days between two groups and UTI group were less volatile. Conclusion Ulinastatin can protect liver function and enhance immune function during the combination of hepatic artery and portal vein chemotherapy after resection of hepatocellular carcinoma ......
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