孕三烯酮和米非司酮对子宫腺肌病病灶TNF和VEGF的表达的研究(1)
【中图分类号】R711.7【文献标识码】A【文章编号】1005-2720(2010)01 - 010 - 04
【摘要】目的 探讨孕三烯酮和米非司酮对子宫腺肌病病灶TNF和VEGF的表达,以及两种因子与痛经评分、子宫体积指标的相关性。方法 设未用药组为对照组,对30例子宫腺肌病子宫标本进行免疫组化染色,检测病灶组织中VEGF和TNF表达;用药组患者在停药后1个月、未用药组在术前分别进行痛经评分,以及术前通过妇科B超监测子宫体积大小。结果 (1)经统计,用药组的子宫腺肌病病灶VEGF和TNF表达均较未用药组低,P=0.0000<0.05。(2)未用药组的VEGF与子宫体积呈正相关,Pearson相关系数为0.641,P=0.046<0.05;三组数据统计得TNF与VEGF呈正相关关系,Pearson相关系数为0.647,P=0.000;TNF与痛经评分呈正相关关系,Pearson相关系数为0.397,P=0.030。结论 子宫腺肌病病灶组织中的VEGF和TNF的表达强弱,显示了异位子宫内膜的生长能力、血管生成能力及病灶局部的炎症免疫反应情况。子宫腺肌病临床症状的轻重程度,与异位子宫内膜病灶组织VEGF和TNF的表达成正相关性。米非司酮和孕三烯酮都可以通过降低VEGF和TNF的表达,改善子宫腺肌病临床症状。
, 百拇医药
【关键词】子宫腺肌病;米非司酮;孕三烯酮;VEGF;TNF
A study of gestrinone and mifepristone affecting the expression of VEGF and TNF in adenomyosis amples
Li Meiliing1Hanke2
(1,Department of Obstetrics and Gynecology, Nanjing General Hospital of Nanjing Military Command;
2,Communicate Editor, Department of Gynecology of Nan Jing Gulou Hospital Affiliated Nan Jing University)
, http://www.100md.com
【Abstract】Objective Appproching Mifepristone and Gestrinone affectingthe expression of VEGF and TNF in adenomyosis tissue,analyzingthe connection between the two factors anduterus volume and menorrhalgia symptom quantization score Methods Setting no-medication patients as control group , testing the expression of VEGF and TNF in adenomyosis tissue of 30 Adenomyosis patients by immunohistochemistry method. The patients of Mifepristone and Gestrinone group are given the mark of menorrhalgia symptom and tested uterus volume while they stopped taking medicine for 1 month .The no-medication patients are taken the information before operation. Results (1)The expression of VEGF and TNF in adenomyosis tissue of medicine groups obviously lower than that of the no-medicine group. P=0.0000<0.05。(2)The expression of VEGF has a positive correlation with uterus volume, the coefficient correlation is 0.641,P=0.046<0.05. Statistic the data ofthree groups ,the expression of TNF has a positive correlation with the expression of VEGF, the coefficient correlation is 0.647,P=0.000; The expression of TNF has a positive correlation with the clinical symptom quantization score, the coefficient correlation is 0.408,P=0.025; The expression of TNF has a positive correlation with menorrhalgia symptom quantization score, the coefficient correlation is 0.397,P=0.030。Conclusion The strong or weak expression of VEGF and TNF in adenomyosis tissue means the growth ability and vascular growth ability of dystopia endometria ,and the inflammation immunity condition of local pathological changed tissue .The degree of the clinical symptom score of the adenomyosis has conformity with the strong or weak expression of VEGF and TNF in adenomyosis tissue. Both Mifepristone and Gestrinone canimprove the clinical symptom by repressingthe expression of VEGF and TNF.
, http://www.100md.com
【Key words】Adenomyosis;Mifepristone;Gestrinone;VEGF;TNF
子宫腺肌病(Adenomyosis)是妇科领域常见疾病,严重危害妇女身心健康,近年来发病率逐年升高,但发病机理尚不十分清楚。研究报道内膜细胞的转移及种植、血管生成等类似肿瘤的生物学行为可能是发病的关键[1]。该病具有转移、浸润和复发的特点,治疗困难。随着患者年轻化、要求保留生育能力的患者增多,子宫腺肌病的药物治疗应用越来越广泛,近年来临床有应用米非司酮和孕三烯酮治疗子宫腺肌病的较多报道,但对于此两种药物的作用机制、临床疗效差异等并无明确阐述。本文仅从米非司酮和孕三烯酮对子宫腺肌病病灶组织中血管内皮生长因子(vascular endothelial growth factor ,VEGF)和肿瘤坏死因子(Tumor necrosis factor-α, TNF-α)表达以及两种因子的表达与临床症状体征的相关性,对米非司酮和孕三烯酮治疗子宫腺肌病的机制做一初探。, 百拇医药(李美玲 韩克)
【摘要】目的 探讨孕三烯酮和米非司酮对子宫腺肌病病灶TNF和VEGF的表达,以及两种因子与痛经评分、子宫体积指标的相关性。方法 设未用药组为对照组,对30例子宫腺肌病子宫标本进行免疫组化染色,检测病灶组织中VEGF和TNF表达;用药组患者在停药后1个月、未用药组在术前分别进行痛经评分,以及术前通过妇科B超监测子宫体积大小。结果 (1)经统计,用药组的子宫腺肌病病灶VEGF和TNF表达均较未用药组低,P=0.0000<0.05。(2)未用药组的VEGF与子宫体积呈正相关,Pearson相关系数为0.641,P=0.046<0.05;三组数据统计得TNF与VEGF呈正相关关系,Pearson相关系数为0.647,P=0.000;TNF与痛经评分呈正相关关系,Pearson相关系数为0.397,P=0.030。结论 子宫腺肌病病灶组织中的VEGF和TNF的表达强弱,显示了异位子宫内膜的生长能力、血管生成能力及病灶局部的炎症免疫反应情况。子宫腺肌病临床症状的轻重程度,与异位子宫内膜病灶组织VEGF和TNF的表达成正相关性。米非司酮和孕三烯酮都可以通过降低VEGF和TNF的表达,改善子宫腺肌病临床症状。
, 百拇医药
【关键词】子宫腺肌病;米非司酮;孕三烯酮;VEGF;TNF
A study of gestrinone and mifepristone affecting the expression of VEGF and TNF in adenomyosis amples
Li Meiliing1Hanke2
(1,Department of Obstetrics and Gynecology, Nanjing General Hospital of Nanjing Military Command;
2,Communicate Editor, Department of Gynecology of Nan Jing Gulou Hospital Affiliated Nan Jing University)
, http://www.100md.com
【Abstract】Objective Appproching Mifepristone and Gestrinone affectingthe expression of VEGF and TNF in adenomyosis tissue,analyzingthe connection between the two factors anduterus volume and menorrhalgia symptom quantization score Methods Setting no-medication patients as control group , testing the expression of VEGF and TNF in adenomyosis tissue of 30 Adenomyosis patients by immunohistochemistry method. The patients of Mifepristone and Gestrinone group are given the mark of menorrhalgia symptom and tested uterus volume while they stopped taking medicine for 1 month .The no-medication patients are taken the information before operation. Results (1)The expression of VEGF and TNF in adenomyosis tissue of medicine groups obviously lower than that of the no-medicine group. P=0.0000<0.05。(2)The expression of VEGF has a positive correlation with uterus volume, the coefficient correlation is 0.641,P=0.046<0.05. Statistic the data ofthree groups ,the expression of TNF has a positive correlation with the expression of VEGF, the coefficient correlation is 0.647,P=0.000; The expression of TNF has a positive correlation with the clinical symptom quantization score, the coefficient correlation is 0.408,P=0.025; The expression of TNF has a positive correlation with menorrhalgia symptom quantization score, the coefficient correlation is 0.397,P=0.030。Conclusion The strong or weak expression of VEGF and TNF in adenomyosis tissue means the growth ability and vascular growth ability of dystopia endometria ,and the inflammation immunity condition of local pathological changed tissue .The degree of the clinical symptom score of the adenomyosis has conformity with the strong or weak expression of VEGF and TNF in adenomyosis tissue. Both Mifepristone and Gestrinone canimprove the clinical symptom by repressingthe expression of VEGF and TNF.
, http://www.100md.com
【Key words】Adenomyosis;Mifepristone;Gestrinone;VEGF;TNF
子宫腺肌病(Adenomyosis)是妇科领域常见疾病,严重危害妇女身心健康,近年来发病率逐年升高,但发病机理尚不十分清楚。研究报道内膜细胞的转移及种植、血管生成等类似肿瘤的生物学行为可能是发病的关键[1]。该病具有转移、浸润和复发的特点,治疗困难。随着患者年轻化、要求保留生育能力的患者增多,子宫腺肌病的药物治疗应用越来越广泛,近年来临床有应用米非司酮和孕三烯酮治疗子宫腺肌病的较多报道,但对于此两种药物的作用机制、临床疗效差异等并无明确阐述。本文仅从米非司酮和孕三烯酮对子宫腺肌病病灶组织中血管内皮生长因子(vascular endothelial growth factor ,VEGF)和肿瘤坏死因子(Tumor necrosis factor-α, TNF-α)表达以及两种因子的表达与临床症状体征的相关性,对米非司酮和孕三烯酮治疗子宫腺肌病的机制做一初探。, 百拇医药(李美玲 韩克)