PCI对慢性稳定性冠心病患者血管内皮功能、血清hs—CRP水平的影响(1)
摘 要：目的 探讨经皮冠状动脉介入术治疗慢性稳定性冠心病的疗效及对患者血管内皮功能、血清hs-CRP水平的影响。方法 收集我院自2015年9月～2017年10月收治的慢性稳定性冠心病患者120例作为观察对象，按治疗方式的不同分为观察组与对照组，每组60例。对照组给予冠状动脉旁路移植术(CABG)治疗，观察组则给予PCI治疗。观察并比较两组治疗有效率，血管内皮功能、血清hs-CRP水平变化情况。结果 观察组治疗总有效率为91.67%，高于对照组的76.67%，差异有统计学意义(P<0.05)。观察组血管内皮功能相关指标及血清hs-CRP水平优于对照组，差异有统计学意义(P<0.05)。结论 PCI治疗慢性稳定性冠心病疗效显著，可快速恢复患者血管内皮功能及血清hs-CRP水平，安全有效。
关键词：PCI；慢性稳定性冠心病；hs-CRP
中图分类号：R541.4 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.12.026
, http://www.100md.com
文章编号：1006-1959(2018)12-0087-03
Abstract：Objective To investigate the efficacy of percutaneous coronary intervention in the treatment of chronic stable coronary heart disease and its effect on endothelial function and serum hs-CRP levels.Methods A total of 120 patients with chronic stable coronary heart disease who were admitted to our hospital from September 2015 to October 2017 were collected as observation objects. According to the treatment methods，they were divided into observation group and control group，with 60 cases in each group.The control group received coronary artery bypass grafting(CABG)and the observation group received PCI.Observe and compare the therapeutic efficacy，vascular endothelial function and serum hs-CRP levels in the two groups.Results The total effective rate of observation group was 91.67%，which was higher than 76.67% of the control group，the difference was statistically significant(P<0.05). The related indicators of vascular endothelial function and serum hs-CRP levels in the observation group were better than those in the control group，and the difference was statistically significant(P<0.05).Conclusion PCI has a significant effect on the treatment of chronic stable coronary artery disease.It can quickly restore the vascular endothelial function and serum hs-CRP levels，which is safe and effective.
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Key words：PCI；Chronic stable coronary heart disease；hs-CRP
慢性穩定性冠心病患者在改善生活方式以及接受规范化药物治疗之后，大部分患者仍然会持续出现心绞痛以及心衰等症状，部分患者甚至可因出现急性心肌梗死而死亡[1]。因此，为了进一步预防此类症状的发生，此类患者需行冠状动脉血运重建治疗[2]。但目前临床上存在两种血运重建方式，一种为冠状动脉旁路移植术(coronary artery bypass grafting， CABG)，另一种为经皮冠状动脉介入术( percutaneous coronary intervention，PCI)，而何种术式可以减少血管内皮功能损伤、避免超敏C-反应蛋白(hs-CRP)等炎症因子水平的释放的相关报道较少。为此，我院比较了CABG与PCI在治疗慢性稳定性冠心病中的临床价值，现将相关结果报道如下。
1资料与方法
, http://www.100md.com
1.1一般资料 收集佳木斯市中心医院自2015年9月～2017年10月收治的慢性稳定性冠心病患者120例作为观察对象，本研究经我院医学伦理会批准同意，患者均知情治疗过程且同意参与本组研究。按治疗方式的不同分为观察组与对照组，每组60例。观察组中男40例，女20例；年龄61～78岁，平均年龄(65.42±3.10)岁；病程1～10年，平均病程(5.62±2.14)年；合并症：高血压42例，高血脂24例，糖尿病18例；血管病变数1～3支，平均病变数(1.86±0.43)支。对照组中男39例，女21例；年龄60～81岁，平均年龄(65.51±3.24)岁；病程1～9年，平均病程(5.71±2.08)年；合并症：高血压44例，高血脂21例，糖尿病19例；血管病变数1～3支，平均病变数(1.90±0.45)支。两组在基线资料方面比较，差异无统计学意义(P>0.05)，具有可比性。, http://www.100md.com(李铎)
关键词：PCI；慢性稳定性冠心病；hs-CRP
中图分类号：R541.4 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.12.026
, http://www.100md.com
文章编号：1006-1959(2018)12-0087-03
Abstract：Objective To investigate the efficacy of percutaneous coronary intervention in the treatment of chronic stable coronary heart disease and its effect on endothelial function and serum hs-CRP levels.Methods A total of 120 patients with chronic stable coronary heart disease who were admitted to our hospital from September 2015 to October 2017 were collected as observation objects. According to the treatment methods，they were divided into observation group and control group，with 60 cases in each group.The control group received coronary artery bypass grafting(CABG)and the observation group received PCI.Observe and compare the therapeutic efficacy，vascular endothelial function and serum hs-CRP levels in the two groups.Results The total effective rate of observation group was 91.67%，which was higher than 76.67% of the control group，the difference was statistically significant(P<0.05). The related indicators of vascular endothelial function and serum hs-CRP levels in the observation group were better than those in the control group，and the difference was statistically significant(P<0.05).Conclusion PCI has a significant effect on the treatment of chronic stable coronary artery disease.It can quickly restore the vascular endothelial function and serum hs-CRP levels，which is safe and effective.
, http://www.100md.com
Key words：PCI；Chronic stable coronary heart disease；hs-CRP
慢性穩定性冠心病患者在改善生活方式以及接受规范化药物治疗之后，大部分患者仍然会持续出现心绞痛以及心衰等症状，部分患者甚至可因出现急性心肌梗死而死亡[1]。因此，为了进一步预防此类症状的发生，此类患者需行冠状动脉血运重建治疗[2]。但目前临床上存在两种血运重建方式，一种为冠状动脉旁路移植术(coronary artery bypass grafting， CABG)，另一种为经皮冠状动脉介入术( percutaneous coronary intervention，PCI)，而何种术式可以减少血管内皮功能损伤、避免超敏C-反应蛋白(hs-CRP)等炎症因子水平的释放的相关报道较少。为此，我院比较了CABG与PCI在治疗慢性稳定性冠心病中的临床价值，现将相关结果报道如下。
1资料与方法
, http://www.100md.com
1.1一般资料 收集佳木斯市中心医院自2015年9月～2017年10月收治的慢性稳定性冠心病患者120例作为观察对象，本研究经我院医学伦理会批准同意，患者均知情治疗过程且同意参与本组研究。按治疗方式的不同分为观察组与对照组，每组60例。观察组中男40例，女20例；年龄61～78岁，平均年龄(65.42±3.10)岁；病程1～10年，平均病程(5.62±2.14)年；合并症：高血压42例，高血脂24例，糖尿病18例；血管病变数1～3支，平均病变数(1.86±0.43)支。对照组中男39例，女21例；年龄60～81岁，平均年龄(65.51±3.24)岁；病程1～9年，平均病程(5.71±2.08)年；合并症：高血压44例，高血脂21例，糖尿病19例；血管病变数1～3支，平均病变数(1.90±0.45)支。两组在基线资料方面比较，差异无统计学意义(P>0.05)，具有可比性。, http://www.100md.com(李铎)