基于数据挖掘分析GPR35表达对肺腺癌预后的影响(1)
摘 要：目的 研究數据挖掘分析GPR35表达对肺腺癌预后的影响，并明晰其参与的分析调控网络。方法 利用Oncomine数据库挖掘GPR35在肺腺癌组织中的表达情况；利用Kaplan-Meier Plotter进行肺腺癌患者生存周期分析；利用Coexpedia数据库分析GPR35参与的分子调控网络。结果 GPR35在人体正常组织中均有表达，其中胰腺组织和骨髓来源的CD33+细胞含量较高。相比于正常肺组织，GPR35基因在肺腺癌组织中呈现高表达，而在肺鳞癌以及大细胞肺癌中，未见明显变化。GPR35基因在肺腺癌组织中，男性患者相对于女性患者呈现高表达，而其表达在StageⅠ和StageⅣ均明显上调，且StageⅣ中GPR35的表达高于其他三期的患者；肺腺癌组织中存在EGFR L858R突变的患者，其GPR35的表达相对于无突变的患者明显上调。GPR35的表达水平对肺腺癌患者的总生存时间有着显著影响。与低表达组相比，GPR35高表达组肺腺癌患者的总存活时间降低(P<0.05)；GPR35的表达水平对LUSC患者的总生存时间未见显著影响(P>0.05)。GPR35参与多种肿瘤相关的分子调控网络。结论 大样本数据挖掘能迅速准确地获取肺腺癌组织中GPR35表达的相关信息，为深入研究奠定基础。
, 百拇医药
关键词：肺腺癌；GPR35；数据挖掘；Oncomine 数据库
中图分类号：R734.2 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.23.024
文章编号：1006-1959(2018)23-0086-06
Abstract：Objective The expression of GPR35 has been found in many tissues and cells. However， no systemic research on lung adenocarcinoma was reported. Methods The Oncomine database was used to explore the expression of GPR35 in lung adenocarcinoma tissues. Kaplan-Meier Plotter was used to analyze the life cycle of lung adenocarcinoma patients. The Coexpedia database was used to analyze the molecular regulatory network involved in GPR35. Results GPR35 was expressed in normal human tissues， and the content of CD33+ cells in pancreatic tissue and bone marrow was higher. Compared with normal lung tissue， GPR35 gene showed high expression in lung adenocarcinoma tissues， but no significant changes in lung squamous cell carcinoma and large cell lung cancer. GPR35 gene in lung adenocarcinoma tissues， male patients showed high expression compared with female patients， and its expression was significantly up-regulated in both StageI and Stage IV， and the expression of GPR35 in Stage IV was higher than that in other three stages； the presence of lung adenocarcinoma In patients with the EGFR L858R mutation， the expression of GPR35 was significantly up-regulated relative to patients without mutation. The expression level of GPR35 has a significant effect on the overall survival of patients with lung adenocarcinoma. Compared with the low expression group， the total survival time of patients with GPR35 high expression group was decreased (P<0.05)；The expression level of GPR35 had no significant effect on the overall survival time of LUSC patients (P>0.05). GPR35 is involved in a variety of tumor-related molecular regulatory networks. Conclusion Large-scale data mining can quickly and accurately obtain information about the expression of GPR35 in lung adenocarcinoma， which lays a foundation for further research., http://www.100md.com(葛丽艳 王琦 朱宏)
, 百拇医药
关键词：肺腺癌；GPR35；数据挖掘；Oncomine 数据库
中图分类号：R734.2 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.23.024
文章编号：1006-1959(2018)23-0086-06
Abstract：Objective The expression of GPR35 has been found in many tissues and cells. However， no systemic research on lung adenocarcinoma was reported. Methods The Oncomine database was used to explore the expression of GPR35 in lung adenocarcinoma tissues. Kaplan-Meier Plotter was used to analyze the life cycle of lung adenocarcinoma patients. The Coexpedia database was used to analyze the molecular regulatory network involved in GPR35. Results GPR35 was expressed in normal human tissues， and the content of CD33+ cells in pancreatic tissue and bone marrow was higher. Compared with normal lung tissue， GPR35 gene showed high expression in lung adenocarcinoma tissues， but no significant changes in lung squamous cell carcinoma and large cell lung cancer. GPR35 gene in lung adenocarcinoma tissues， male patients showed high expression compared with female patients， and its expression was significantly up-regulated in both StageI and Stage IV， and the expression of GPR35 in Stage IV was higher than that in other three stages； the presence of lung adenocarcinoma In patients with the EGFR L858R mutation， the expression of GPR35 was significantly up-regulated relative to patients without mutation. The expression level of GPR35 has a significant effect on the overall survival of patients with lung adenocarcinoma. Compared with the low expression group， the total survival time of patients with GPR35 high expression group was decreased (P<0.05)；The expression level of GPR35 had no significant effect on the overall survival time of LUSC patients (P>0.05). GPR35 is involved in a variety of tumor-related molecular regulatory networks. Conclusion Large-scale data mining can quickly and accurately obtain information about the expression of GPR35 in lung adenocarcinoma， which lays a foundation for further research., http://www.100md.com(葛丽艳 王琦 朱宏)