奥美拉唑与西咪替丁治疗应激性胃溃疡的疗效观察(1)
摘 要：目的 观察奥美拉唑与西咪替丁治疗应激性胃溃疡的临床效果及对患者生活质量的影响。方法 选择2016年1月～2018年1月我院收治的64例应激性胃溃疡患者，随机分为观察组和对照组，各32例。对照组患者应用西咪替丁治疗，观察组应用奥美拉唑治疗。比较两组患者的临床疗效、止血时间、胃泌素水平、生活质量评分及不良反应发生率。结果 观察组患者总有效率为96.88%，高于对照组的78.13%，差异有统计学意义(P<0.05)；治疗后，观察组患者胃泌素水平低于对照组[(95.24±2.36)pg/ml vs (112.48±2.26)pg/ml] ，差异有统计学意义(P<0.05)；观察组患者止血时间短于对照组，且生活质量评分高于对照组，差异有统计学意义(P<0.05)；观察组患者不良反应发生率为3.13%，低于对照组的18.75%，差异有统计学意义(P<0.05)。结论 对应激性胃溃疡患者实施奥美拉唑的效果较西咪替丁更佳，且更有助于提升患者日常生活质量。
关键词：应激性胃溃疡；奥美拉唑；西咪替丁；生活质量
, 百拇医药
中图分类号：R573.1 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.23.039
文章编号：1006-1959(2018)23-0136-03
Abstract：Objective To observe the clinical effect of Omeprazole and Cimetidine in the treatment of stress gastric ulcer and their effect on the quality of life of patients.Methods 64 patients with stress gastric ulcer from January 2016 to January 2018 were randomly divided into observation group and control group with 32 cases in each group.The control group was treated with Cimetidine and the observation group with Omeprazole.The clinical efficacy， hemostatic time， gastrin level， quality of life score and incidence of adverse reactions were compared between the two groups.Results The total effective rate in the observation group was 96.88%， which was higher than that in the control group 78.13%，the difference was statistically significant (P<0.05).After treatment， gastrin levels in the observation group were lower than those in the control group [(95.24 ±2.36) pg/ml vs (112.48 ±2.26) pg/ml]，the difference was statistically significant (P<0.05).The hemostatic time of the patients in the observation group was shorter than that in the control group， and the score of quality of life in the observation group was higher than that in the control group，the difference was statistically significant (P<0.05).The incidence of adverse reactions in the observation group was 3.13%， which was significantly lower than that in the control group 18.75%，the difference was statistically significant (P<0.05).Conclusion The effect of Omeprazole on patients with stress gastric ulcer is better than Cimetidine， and it is more helpful to improve the quality of daily life.
, 百拇医药
Key words：Stress gastric ulcer；Omeprazole；Cimetidine；Quality of life
應激性胃溃疡(stress gastric ulcer)的患病率呈现逐年增加的趋势，该疾病属于临床常见的消化内科疾病之一，具有病情危急、进展快速等特点[1]，若治疗不及时，患者可出现胃穿孔、休克等并发症，严重者可致死，对其生命安全构成了严重威胁。因此，对患者实施有效干预十分关键。药物疗法是治疗应激性胃溃疡的有效手段，而如何安全、有效治疗应激性胃溃疡已经成为临床关注的热点问题，其中奥美拉唑、西咪替丁均属于临床治疗应激性胃溃疡的常用药物，但目前临床关于上述2种药物的疗效及安全性依然存在一定争议[2]。为对比奥美拉唑、西咪替丁的临床疗效，我院对应激性胃溃疡患者分别应用奥美拉唑、西咪替丁治疗，现报道如下。, http://www.100md.com(高华初)
关键词：应激性胃溃疡；奥美拉唑；西咪替丁；生活质量
, 百拇医药
中图分类号：R573.1 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.23.039
文章编号：1006-1959(2018)23-0136-03
Abstract：Objective To observe the clinical effect of Omeprazole and Cimetidine in the treatment of stress gastric ulcer and their effect on the quality of life of patients.Methods 64 patients with stress gastric ulcer from January 2016 to January 2018 were randomly divided into observation group and control group with 32 cases in each group.The control group was treated with Cimetidine and the observation group with Omeprazole.The clinical efficacy， hemostatic time， gastrin level， quality of life score and incidence of adverse reactions were compared between the two groups.Results The total effective rate in the observation group was 96.88%， which was higher than that in the control group 78.13%，the difference was statistically significant (P<0.05).After treatment， gastrin levels in the observation group were lower than those in the control group [(95.24 ±2.36) pg/ml vs (112.48 ±2.26) pg/ml]，the difference was statistically significant (P<0.05).The hemostatic time of the patients in the observation group was shorter than that in the control group， and the score of quality of life in the observation group was higher than that in the control group，the difference was statistically significant (P<0.05).The incidence of adverse reactions in the observation group was 3.13%， which was significantly lower than that in the control group 18.75%，the difference was statistically significant (P<0.05).Conclusion The effect of Omeprazole on patients with stress gastric ulcer is better than Cimetidine， and it is more helpful to improve the quality of daily life.
, 百拇医药
Key words：Stress gastric ulcer；Omeprazole；Cimetidine；Quality of life
應激性胃溃疡(stress gastric ulcer)的患病率呈现逐年增加的趋势，该疾病属于临床常见的消化内科疾病之一，具有病情危急、进展快速等特点[1]，若治疗不及时，患者可出现胃穿孔、休克等并发症，严重者可致死，对其生命安全构成了严重威胁。因此，对患者实施有效干预十分关键。药物疗法是治疗应激性胃溃疡的有效手段，而如何安全、有效治疗应激性胃溃疡已经成为临床关注的热点问题，其中奥美拉唑、西咪替丁均属于临床治疗应激性胃溃疡的常用药物，但目前临床关于上述2种药物的疗效及安全性依然存在一定争议[2]。为对比奥美拉唑、西咪替丁的临床疗效，我院对应激性胃溃疡患者分别应用奥美拉唑、西咪替丁治疗，现报道如下。, http://www.100md.com(高华初)