RNA病毒的RNA聚合酶研究进展(3)
[7]Van Dyke, T. A., and Flanegan, J. B. (1980). Identification of poliovirus polypeptide p63 as soluble RNA-dependent RNA polymerase. J. Virol. 35, 733-740.
[8]Behrens, S. E., Tomei, L., and De Francesco, R. (1997). Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus. EMBO J. 15, 12-22.
[9]Lohmann, V., Kroner, F., Herian, U., and Bartenschlager, R. (1997). Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity. J. Virol. 71, 8416-8428.
, 百拇医药
[10]Yuan, Z. H., Kumar, U., Thomas, H. C., Wen, Y. M., and Monjardino, J. (1997). Expression, purification, and partial characterization of HCV RNA polymerase. Biochem. Biophys. Res. Commun. 232, 231-235.
[11]Hong, Y., and Hunt, A. G. (1996). RNA polymerase activity catalyzed by a potyvirus-encoded RNA-dependent RNA polymerase. Virology 226, 146-151.
[12]Koonin, E. V. (1991). The phylogeny of RNA-dependent RNA polymerases of positive-strand RNA viruses. J. Gen. Virol. 72, 2197-2206.
, 百拇医药
[13]Poch, O., Sauvaget, I., Delarue, M., and Tordo, N. (1989). Identification of four conserved motifs among the RNA-dependent polymerase encoding elements. EMBO J. 12, 3867-3874.
[14]Hansen, J. L., Long, A. M., and Schultz, S. C. (1997). Structure of the RNA-dependent RNA polymerase of poliovirus. Structure 5, 1109-1122.
[15]Ollis, D. L., Brick, P., Hamlin, R., Xuong, N. G., and Steitz, T. A. (1985). Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP. Nature 313, 762
, 百拇医药
[16]Kohlstaedt, L. A., Wang, J., Friedman, J. M., Rice, P. A., and Steitz, T. A. (1992). Crystal structure at 3.5 ? resolution of HIV-1 reverse transcriptase complexed wit an inhibitor. Science 256, 1783-1790.
[17]Steitz, T. A. (1993). DNA and RNA-dependent DNA polymerases. Curr. Opin. Struct. Biol. 3, 31.
[18]Sousa, R., Chung, Y. J., Rose, J. P., and Wang, B. (1993). Crystal structure of bacteriophge T7 RNA polymerase at 3.3 resolution. Nature 364, 593-599.
, 百拇医药
[19]Jacobo-Molina, A., Ding, J., Nanni, R. G., Clark, A. D., Jr., Lu, X., Tantillo, C., Williams, R. L., Kamer, G., Ferris, A. L., Clark, P., Hizi, A., Hughes, S. H., and Arnold, E. (1993). Crystal structure of human immunodeficiency virus type I reverse transcriptase complexed with doublestranded DNA at 3.0 ? resolution shows bent DNA. Proc. Natl. Acad. Sci. USA 90, 6320-6324.
[20]Beese, L. S., Derbyshire, V., and Steitz, T. A. (1993). Structure of DNA polymerase I Klenow fragment bound to duplex DNA. Science 260, 352-355.
, 百拇医药
[21]Kiefer, J. R., Mao, C., Braman, J. C., and Beese, L. S Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal. Nature ,1998,91, 304-307.
[22]Eom, S. H., Wang, J., and Steitz, T. (1996). Structure of Taq polymerase with DNA at the polymerase active site. Nature 382, 278-281.
[23]Doublie′ , S., Stanley, T., Long, A. M., Richardson, C. C., and Ellenberger, T. (1998). Crystal structure of a bacteriophage T7 DNA replication complex at 2.2resolution. Nature 391, 251
, 百拇医药
[24]Seeman, N. C., Rosenberg, J. M., and Rich, A. (1976). A sequencespecific recognition of double helical nucleic acids by proteins. Proc. Natl. Acad. Sci. USA 73, 804-808.
[25]Steitz, T. A. (1998). A mechanism for all polymerases. Nature 391, 231-232.
[26]Beese, L. S., and Steitz, T. A. (1991). Structural basis for the 39-59 exonuclease activity of Escherichia coli DNA polymerase I: A two metal ion mechanism. EMBO J. 10, 25-33.
(收稿日期：2009.03.10), 百拇医药(王晓芳)
[8]Behrens, S. E., Tomei, L., and De Francesco, R. (1997). Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus. EMBO J. 15, 12-22.
[9]Lohmann, V., Kroner, F., Herian, U., and Bartenschlager, R. (1997). Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity. J. Virol. 71, 8416-8428.
, 百拇医药
[10]Yuan, Z. H., Kumar, U., Thomas, H. C., Wen, Y. M., and Monjardino, J. (1997). Expression, purification, and partial characterization of HCV RNA polymerase. Biochem. Biophys. Res. Commun. 232, 231-235.
[11]Hong, Y., and Hunt, A. G. (1996). RNA polymerase activity catalyzed by a potyvirus-encoded RNA-dependent RNA polymerase. Virology 226, 146-151.
[12]Koonin, E. V. (1991). The phylogeny of RNA-dependent RNA polymerases of positive-strand RNA viruses. J. Gen. Virol. 72, 2197-2206.
, 百拇医药
[13]Poch, O., Sauvaget, I., Delarue, M., and Tordo, N. (1989). Identification of four conserved motifs among the RNA-dependent polymerase encoding elements. EMBO J. 12, 3867-3874.
[14]Hansen, J. L., Long, A. M., and Schultz, S. C. (1997). Structure of the RNA-dependent RNA polymerase of poliovirus. Structure 5, 1109-1122.
[15]Ollis, D. L., Brick, P., Hamlin, R., Xuong, N. G., and Steitz, T. A. (1985). Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP. Nature 313, 762
, 百拇医药
[16]Kohlstaedt, L. A., Wang, J., Friedman, J. M., Rice, P. A., and Steitz, T. A. (1992). Crystal structure at 3.5 ? resolution of HIV-1 reverse transcriptase complexed wit an inhibitor. Science 256, 1783-1790.
[17]Steitz, T. A. (1993). DNA and RNA-dependent DNA polymerases. Curr. Opin. Struct. Biol. 3, 31.
[18]Sousa, R., Chung, Y. J., Rose, J. P., and Wang, B. (1993). Crystal structure of bacteriophge T7 RNA polymerase at 3.3 resolution. Nature 364, 593-599.
, 百拇医药
[19]Jacobo-Molina, A., Ding, J., Nanni, R. G., Clark, A. D., Jr., Lu, X., Tantillo, C., Williams, R. L., Kamer, G., Ferris, A. L., Clark, P., Hizi, A., Hughes, S. H., and Arnold, E. (1993). Crystal structure of human immunodeficiency virus type I reverse transcriptase complexed with doublestranded DNA at 3.0 ? resolution shows bent DNA. Proc. Natl. Acad. Sci. USA 90, 6320-6324.
[20]Beese, L. S., Derbyshire, V., and Steitz, T. A. (1993). Structure of DNA polymerase I Klenow fragment bound to duplex DNA. Science 260, 352-355.
, 百拇医药
[21]Kiefer, J. R., Mao, C., Braman, J. C., and Beese, L. S Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal. Nature ,1998,91, 304-307.
[22]Eom, S. H., Wang, J., and Steitz, T. (1996). Structure of Taq polymerase with DNA at the polymerase active site. Nature 382, 278-281.
[23]Doublie′ , S., Stanley, T., Long, A. M., Richardson, C. C., and Ellenberger, T. (1998). Crystal structure of a bacteriophage T7 DNA replication complex at 2.2resolution. Nature 391, 251
, 百拇医药
[24]Seeman, N. C., Rosenberg, J. M., and Rich, A. (1976). A sequencespecific recognition of double helical nucleic acids by proteins. Proc. Natl. Acad. Sci. USA 73, 804-808.
[25]Steitz, T. A. (1998). A mechanism for all polymerases. Nature 391, 231-232.
[26]Beese, L. S., and Steitz, T. A. (1991). Structural basis for the 39-59 exonuclease activity of Escherichia coli DNA polymerase I: A two metal ion mechanism. EMBO J. 10, 25-33.
(收稿日期：2009.03.10), 百拇医药(王晓芳)