VEGF明胶缓释微球对大鼠背部随意皮瓣存活的影响(3)
本实验显示缓释微球能显著延长VEGF的作用效果，能显著增加皮瓣与受区的血管新生，增加皮瓣的血流量，从而促进皮瓣的存活率及生存质量，但如何提高微球的载药率、延长微球的缓释作用还需进一步研究，为其早日应用于临床奠定坚实的基础。
[参考文献]
[1]LinP,Sankar S，et al.Inhibition of tumor growth by targeting tumer endothelium using a soluble vascular endothelial growth factor receptor.Cell Growth Differ 1998,9(1):49-58.
[2]Stepnick DW, PetersonMK, Bodgan C, et al. Effects of tumor necrosis factor alpha and vascular permeability factor on neovascularisation of the rabbit ear flap [J]. Arch Otolaryngol Head Neck Surg 1995；121(6):667.
[3]Khan A，Ashrafpour H，Huang N，et a1.Acute local subcutaneous VEGF165 injection for augmentation of skin flap viability：efficacy and mechanism[J].Am J Physiol Regul Integr Comp Physiol，2004，287(5)：R1219.
[4]Nimni ME. Polypeptide growth factors:targeted delivery systems[J].Bio Materials,1997,18:1201-1225.
[5]隋继强,韩 岩,吴 红，等. 人表皮生长因子与碱性成纤维细胞生长因子纳米缓释剂对成纤维细胞的影响[J]. 中国美容医学,2006,15(12):1342-1345.
[6]Kawai K，Suzuki S，Tabata Y，et a1.Accelerated tissue Regeneration through incorporation of basic fibroblast growth factor-impregnated gelatin microspheres into artificial dennis[J].Biomaterials，2000,21(5)：489-499.
[7]Rita C, Elisabetta E, Maria O. Dextran cross-linked gelatin micro2 spheres as a drug delivery system[J]. European J Pharm and Biopharm,1999,47 :153.
[收稿日期]2007-12-17[修回日期]2008-03-11
编辑/张惠娟, http://www.100md.com(王 璐 郭树忠 马显杰 宋保强 伍尚敏 易成刚)
[参考文献]
[1]LinP,Sankar S，et al.Inhibition of tumor growth by targeting tumer endothelium using a soluble vascular endothelial growth factor receptor.Cell Growth Differ 1998,9(1):49-58.
[2]Stepnick DW, PetersonMK, Bodgan C, et al. Effects of tumor necrosis factor alpha and vascular permeability factor on neovascularisation of the rabbit ear flap [J]. Arch Otolaryngol Head Neck Surg 1995；121(6):667.
[3]Khan A，Ashrafpour H，Huang N，et a1.Acute local subcutaneous VEGF165 injection for augmentation of skin flap viability：efficacy and mechanism[J].Am J Physiol Regul Integr Comp Physiol，2004，287(5)：R1219.
[4]Nimni ME. Polypeptide growth factors:targeted delivery systems[J].Bio Materials,1997,18:1201-1225.
[5]隋继强,韩 岩,吴 红，等. 人表皮生长因子与碱性成纤维细胞生长因子纳米缓释剂对成纤维细胞的影响[J]. 中国美容医学,2006,15(12):1342-1345.
[6]Kawai K，Suzuki S，Tabata Y，et a1.Accelerated tissue Regeneration through incorporation of basic fibroblast growth factor-impregnated gelatin microspheres into artificial dennis[J].Biomaterials，2000,21(5)：489-499.
[7]Rita C, Elisabetta E, Maria O. Dextran cross-linked gelatin micro2 spheres as a drug delivery system[J]. European J Pharm and Biopharm,1999,47 :153.
[收稿日期]2007-12-17[修回日期]2008-03-11
编辑/张惠娟, http://www.100md.com(王 璐 郭树忠 马显杰 宋保强 伍尚敏 易成刚)