黑素皮质激素受体-1结构和功能(3)
[13]Barsh G, Gunn T, He L,et al. Biochemical and genetic studies of pigment-type switching[J].Pigment Cell Res,2000,13(Suppl 8):48-53.
[14]Price ER,Horstmann MA, Wells AG, et al. Alpha-melanocyte-stimulating hormone signaling regulates expression of microphthalmia,a gene deficient in Waardenburg syndrome[J].J Biol Chem,1998,273(49):33042-33047.
[15]Suzuki I, Cone RD, Im S,et al.Binding of melanotropic hormones to the melanocortin receptor MC1R on human melanocytes stimulates proliferation and melanogenesis[J].Endocrinology 1996,137(5):1627-1633.
, http://www.100md.com
[16]Abdel-Malek Z,Swope VB, Suzuki I,et al. Mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptides[J].Proc Natl Acad Sci USA,1995,92(5):1789-1793.
[17]Suzuki I, Cone RD, Im S,et al.Binding capacity andactivation of the MC1 receptors by melanotropic hormones correlate directly with their mitogenic and melanogenic effects on human melanocytes[J]. Endocrinology, 1996,137:1627-1633.
[18]Scott G, Cassidy L, Abdel-Malek Z. -Melanocyte-stimulating hormone and endothelin-1 have opposing effects on melanocyte adhesion, migration, and pp125FAK phosphorylation[J]. Exp Cell Res,1997,237(1):19-28.
, 百拇医药
[19]Kwon HY, Bultman SJ, Loffler C，et a1.Molecular structure and chromosomal mapping of the human homolog of the agouti gene[J].Proc Natl Acad Sci USA，1994,91(21):9760-9764.
[20]Voisey J,van Daal A.Agouti: from mouse to man，from skin to fat[J].Pigment Cell Res，2002,15：10-18.
[21]Suzuki I, Tada A,Ollmann MM,et al. Agouti signaling protein inhibits melanogenesis and the response of human melanocytes to alpha-melanotropin[J].J Invest Dermatol,1997,108(6): 838-842.
, 百拇医药
[22]Kobayashi T,Vieira WD,Potterf B,et al.Modulation of melanogenic protein expression during the switch from eu- to pheomelanogenesis[J].J Cell Sci,1995, 108(6): 2301-2309.
[23]Chakraborty A, Slominski A, Ermak G.Ultraviolet B and melanocyte stimulating hormone (MSH) stimulate mRNA production for alpha MSH receptors and proopiomelanocortin derived peptides in mouse melanoma cells and transformed keratinocytes[J]. J Inves Dermatol,1995,105(5): 655-659.
, 百拇医药
[24]Sungbin IM, Osamu Moro, Fuping Peng, et al. Activation of the cAMP pathway by-melanotropin mediates the response of human melanocytes to UVB light[J].J Cancer Res,1998,58:47-54.
[25]Tada A, Suzuki I, Im S, et al. Endothelin-1 is a paracrine growth factor that modulates melanogenesis of human melanocytes and participated in their response to ultraviolet radiation[J]. Cell Growth Differ,1998,9(7): 575-584.
[26]Valverde P,Healy E, Sikkink S,et al.The Asp84Glu variant of the melanocortin 1 receptor (MC1R) is associated with melanoma[J].Hum Mol Genet,1996,5(10): 1663-1666.
, http://www.100md.com
[27]Smith R, Healy E, Siddiqui S,et al.Melanocortin 1 receptor variants in an Irish population[J]. J Invest Dermatol,1998,111(1): 119-122.
[28]Kennedy C,ter Huurne J,Berkhout M,et al.Melanocortin 1 receptor (MC1R) gene variants are associated with an increased risk for cutaneous melanoma which is largely independent of skin type and hair color[J].J Invest Dermatol,2001,117(2):294-300.
[29]Davies H, Bignell GR,Cox C,et al.Mutations of the BRAFgene in human cancer[J].Nature, 2002,417(6892):906-907.
[30]Fargnoli MC, Pike K, Pfeiffer RM,et al. MC1R variants increase risk of melanomas harboring BRAF mutations[J].J Invest Dermatol,2008,128(10):2485-2490.
[收稿日期]2008-10-14[修回日期]2008-12-23
编辑/张惠娟, http://www.100md.com(袁 磊 张余光)
[14]Price ER,Horstmann MA, Wells AG, et al. Alpha-melanocyte-stimulating hormone signaling regulates expression of microphthalmia,a gene deficient in Waardenburg syndrome[J].J Biol Chem,1998,273(49):33042-33047.
[15]Suzuki I, Cone RD, Im S,et al.Binding of melanotropic hormones to the melanocortin receptor MC1R on human melanocytes stimulates proliferation and melanogenesis[J].Endocrinology 1996,137(5):1627-1633.
, http://www.100md.com
[16]Abdel-Malek Z,Swope VB, Suzuki I,et al. Mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptides[J].Proc Natl Acad Sci USA,1995,92(5):1789-1793.
[17]Suzuki I, Cone RD, Im S,et al.Binding capacity andactivation of the MC1 receptors by melanotropic hormones correlate directly with their mitogenic and melanogenic effects on human melanocytes[J]. Endocrinology, 1996,137:1627-1633.
[18]Scott G, Cassidy L, Abdel-Malek Z. -Melanocyte-stimulating hormone and endothelin-1 have opposing effects on melanocyte adhesion, migration, and pp125FAK phosphorylation[J]. Exp Cell Res,1997,237(1):19-28.
, 百拇医药
[19]Kwon HY, Bultman SJ, Loffler C，et a1.Molecular structure and chromosomal mapping of the human homolog of the agouti gene[J].Proc Natl Acad Sci USA，1994,91(21):9760-9764.
[20]Voisey J,van Daal A.Agouti: from mouse to man，from skin to fat[J].Pigment Cell Res，2002,15：10-18.
[21]Suzuki I, Tada A,Ollmann MM,et al. Agouti signaling protein inhibits melanogenesis and the response of human melanocytes to alpha-melanotropin[J].J Invest Dermatol,1997,108(6): 838-842.
, 百拇医药
[22]Kobayashi T,Vieira WD,Potterf B,et al.Modulation of melanogenic protein expression during the switch from eu- to pheomelanogenesis[J].J Cell Sci,1995, 108(6): 2301-2309.
[23]Chakraborty A, Slominski A, Ermak G.Ultraviolet B and melanocyte stimulating hormone (MSH) stimulate mRNA production for alpha MSH receptors and proopiomelanocortin derived peptides in mouse melanoma cells and transformed keratinocytes[J]. J Inves Dermatol,1995,105(5): 655-659.
, 百拇医药
[24]Sungbin IM, Osamu Moro, Fuping Peng, et al. Activation of the cAMP pathway by-melanotropin mediates the response of human melanocytes to UVB light[J].J Cancer Res,1998,58:47-54.
[25]Tada A, Suzuki I, Im S, et al. Endothelin-1 is a paracrine growth factor that modulates melanogenesis of human melanocytes and participated in their response to ultraviolet radiation[J]. Cell Growth Differ,1998,9(7): 575-584.
[26]Valverde P,Healy E, Sikkink S,et al.The Asp84Glu variant of the melanocortin 1 receptor (MC1R) is associated with melanoma[J].Hum Mol Genet,1996,5(10): 1663-1666.
, http://www.100md.com
[27]Smith R, Healy E, Siddiqui S,et al.Melanocortin 1 receptor variants in an Irish population[J]. J Invest Dermatol,1998,111(1): 119-122.
[28]Kennedy C,ter Huurne J,Berkhout M,et al.Melanocortin 1 receptor (MC1R) gene variants are associated with an increased risk for cutaneous melanoma which is largely independent of skin type and hair color[J].J Invest Dermatol,2001,117(2):294-300.
[29]Davies H, Bignell GR,Cox C,et al.Mutations of the BRAFgene in human cancer[J].Nature, 2002,417(6892):906-907.
[30]Fargnoli MC, Pike K, Pfeiffer RM,et al. MC1R variants increase risk of melanomas harboring BRAF mutations[J].J Invest Dermatol,2008,128(10):2485-2490.
[收稿日期]2008-10-14[修回日期]2008-12-23
编辑/张惠娟, http://www.100md.com(袁 磊 张余光)