丹红注射液对慢性阻塞性肺疾病急性加重期患者IL-8\TNF-α影响(1)
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2010年2月1日
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【摘要】目的:观察丹红注射液治疗慢性阻塞性肺疾病急性加重期患者白细胞介素-8(IL-8)和肿瘤坏死因子-α(TNF-α)的影响。方法:将96例慢性阻塞性肺疾病急性加重期患者随机分为治疗组(50例)和对照组(46例),两组均给予常规对症治疗(吸氧、化痰、平喘、抗感染等),治疗组在上述基础上加用丹红注射液40ml+0.9%氯化钠注射液250ml静滴,1次/d,疗程14d。观察两组患者症状体征、血气分析及肺功能指标的变化,同时检测两组患者血清IL-8和TNF-α水平的变化。结果:治疗组临床疗效的总有效率优于对照组(P<0.05);治疗组血清中IL-8和TNF-α浓度较对照组下降,差异有统计学意义(P<0.05或P<0.01)。 结论:丹红注射液可降低COPD急性加重期血清中IL-8和TNF-α浓度,抑制炎症细胞生成,对COPD气道炎症具有明显的抑制作用。
【关键词】丹红注射液;慢性阻塞性肺疾病;白细胞介素-8;肿瘤坏死因子-α
【中图分类号】R563.9 【文献标识码】B 【文章编号】1008-6455(2010)08-0115-02
Efect of Danhong Injection on the expression of Interleukin-8 and Tumor necrosis factor-α
in Acute Exacerbations of Chronic obstructive pulmonary disease patients
Liu Zhong1 Liu Xin2*
【Abstract】Objective:To observe the effect ofDanhong injection on the expression of Interleukin-8 (IL-8) and Tumor necrosis factor-α (TNF-α) in the serum ofAcute Exacerbations of Chronic obstructive pulmonary disease (AECOPD) patients.Methods:96 AECOPD patients were randomly divided into 2 groups: 46 cases in the control group and 50 cases in the treatment group, both groups were treated with common western medical treatment. Only patients in the treatment group were injected with 40ml Danhong injection everyday for 14 days. results of observation showed difierences of the treatment group from the control group. IL-8 and TNF-αin the serum in each group were detected.Results:Total efficiency in treatment group is better than that in control group (P<0.05 );After treatment with Danhong injection. The level of IL-8 and TNF-αof treatment group were lower than that before in treatment or control group (P<0.05 or P<0.01).Conclusion:Danhong injection can decrease the level of IL-8 and TNF-α in the serum in AECOPD patients, and reduce the inflammatory cell, and have protection on airway to patients with AECOPD.
【Key words】Danhong injection; Chronic obstructive pulmonary disease;Interleukin-8;Tumor necrosis factor-α
慢性阻塞性肺疾病(Chronic obstructive pulmonary disease ,COPD)是呼吸系统最常见的疾病之一。由于其患病率及病死率高,社会经济负担重,目前己成为一个全球重要的公共卫生问题[1]。COPD是多种细胞和炎症介质参与的慢性气道炎症反应性疾病,炎症的发生与机体的免疫系统密切相关。白细胞介素-8(IL-8)和肿瘤坏死因子-α(TNF-α)是具有多种免疫功能的调节因子,参与COPD气道炎症反应及气道结构的重塑。本研究旨在观察COPD急性加重期患者使用丹红注射液治疗前后血清IL-8和TNF-α的变化,以探讨丹红注射液在COPD急性加重期过程中的作用及其临床意义。
1 资料与方法
1.1 一般资料:96例患者为我院呼吸科2007年10月至2008年10月收治的慢性阻塞性肺疾病急性加重期(AECOPD)住院患者,均符合中华医学会呼吸学分会慢性阻塞性肺疾病学组2007年制定的《慢性阻塞性肺疾病诊治指南》诊断标准[2],结合患者病史、全面体检、胸部X线片、心电图及肺功能检查确定,排除其他引起咳嗽、咳痰及气急的心肺疾病 ......
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