山茛菪碱佳苏仑在小儿全麻术后催醒效果比较
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2010年2月1日
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【摘要】目的:探讨山茛菪碱(654-2)用于小儿非气管插全麻术后催醒的临床效果。方法:60例患儿,随机分为山茛菪碱组(A)佳苏仑(B),各30例。所有患儿均用氯胺酮+异丙酚麻醉。A 术毕静注654-2 0.2mg/kg,B静注佳苏仑1mg/kg。结果:A用药后10min、20min、30min的苏醒率为26.7%、90%及100%;B分别是30%、96.7%和100%;两组患儿催醒后心率均快于用药前,P>0.05无统计学差异,B苏醒期有一例出现烦躁。观察结果表明654-2和佳苏仑一样具有较好的催醒作用。结论:654-2用于小儿全麻术后催醒,效果确切,无明显不良反应,是可推广的催醒方法。
【关键词】山茛菪碱;小儿全麻;术后催醒
【中图分类号】R614.2 【文献标识码】B 【文章编号】1008-6455(2010)08-0253-02
Anisodamine Doxpram after general anesthesia for children Wake-up effect
Chen Minghua Li Hua Liu Yong
【Abstract】Objective: To observe anisodamine (654-2) for general anesthesia in children after insertion of non-respiratory clinical effects of wake-up. Methods: 60 patients with general anesthesia were divided randomly into anisodamine group (A) good Sulun (B), all 30 cases. All patients were anesthetized with ketamine propofol. A group of surgery intravenous 654-20.2mg/kg, B group of intravenous good Sulun 1mg/kg. Results: A after treatment 10min, 20min, 30min of awakening was 26.7%, 90% and 100%; B were 30%, 96.7% and 100%; two children wake-up heart rate are faster than before treatment, P>0.05 no significant difference, Bupset in one case recovery period. The results suggested thatgoodSulun 654-2 and has a good wake-up the same role. Conclusion:654-2 after general anesthesia for children wake-up, the exact effect, no significant adverse reactions, is a wake-up method can be extended.
【Key words】anisodamine wake-up after general anesthesia in children
本文研究山茛菪碱用于小儿全麻术后催醒的临床效果并与佳苏仑比较。
1 资料与方法
1.1 一般资料:择ASAⅠ-Ⅱ级全麻患儿60例,年龄1-5岁,男38例,女22例,体重9-21公斤,心肺功能及术前检查均正常。小儿疝39例,隐睾5例,阑尾切除3例,斜颈4例,其它9例,手术时间31±1520min,随机分为山茛菪碱组(A)与佳苏仑组(B),各30例。
1.2 麻醉方法:麻醉前常规禁食水,肌注阿托品0.02mg/kg,鲁米那1.5mg/kg,对不合作患儿先肌注氯胺酮4-5mg/kg,开放静脉通道,接监护仪, 切皮前1分钟静注氯胺酮1mg/kg,术中视肢动情况间断注射异丙酚1-2mg/kg 维持麻醉,对手术超过1h的术中酌情追加氯胺酮1mg/kg。 患儿术中均面罩吸氧,氧饱和度(SPO2)维持在98%以上。
1.3 催醒方法:术毕A 静注654-2 0.2mg/kg,B静注佳苏仑1mg/kg; 记录苏醒时间及术毕、术后10min、20min、30min时HR、SPO2,同时观察两组患儿有无不良反应。苏醒标准为:反射恢复,肢体活动明显,自主呼吸,哭闹或服从指令。
苏醒程度采用steward苏醒评分标准。
1.4 统计学处理:采用SAS9.0统计学分析,P<0.05 为有显著性差异。
2 结果
(1)两组患儿年龄、体重、男、女比例及手术时间均无显著差异性P>0.05。
(2)临床观察,A用药后10min、20min、30min的苏醒率为26.7%、90%及100%;B分别是30%、96 ......
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