三七茜草复方干预置Cu-IUD家兔出血副反应的拆方实验研究(1)
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摘 要:目的:对三七茜草复方进行拆方实验研究。方法:建立置Cu-IUD家兔的动物模型,观察三七茜草复方及三七、茜草单独对置Cu-IUD家兔的血液流变学、子宫内膜表浅微血管总数、以及6-K-PGF1α、TXB2、t-PA活性的影响。结果:三七茜草复方及三七、茜草均能减少置器后家兔子宫内膜浅血管数以及降低红细胞比容和低切、中切、高切下全血比黏度及血浆比黏度的作用,同时均能使家兔子宫匀浆6-K-PGF1α/TXB2比值和t-PA活性明显降低,但单用三七或茜草,效果不如复方。结论:三七茜草复方具有改善前列腺素的平衡失调,纤溶系统,血液流变学的异常等病理变化的作用,三七、茜草是其组成的必要药味。
关键词:宫环出血;三七;茜草;6-K-PGF1α;TXB2;t-PA
中图分类号:R285.5 文献标识码:A 文章编号:1673-7717(2010)04-0726-03
Experimental Research to Decompose the SQ
Complex Prescription Treating the Uterine Bleeding of Cu-IUD-Wearing Rabbits
TAN Zhaoyang, YOU Zhaoling,FU Lingmei, YIN Xianghua
(Hunan University of Chinese Medicine, Changsha,410208,Hunan,China)
Abstract:Objective: To decompose the SQ complex prescription which was composed of Radix notoginseng and Radix rubiae. Methods:An animal model of Cu-IUD-wearing rabbits was established and was given SQ complex prescription, Radix notoginseng or Radix rubiae alone. Hemorheology markers, endometrium microvessel count, 6-K-PGF1α, TXB2, and t-PA were studied. Results:SQ complex prescription, Radix notoginseng and Radix rubiae all could reduce the endometrium microvessel count, degrade the erythrocrit, the blood viscosity at low, medium and high shear rate and the plasma viscosity of Cu-IUD-wearing rabbits, decrease the ratio of 6-K-P/TXB2 and t-PA activity obviously. But the effects of Radix notoginseng or Radix rubiae were weaker than that of SQ. Conclusion: SQ complex prescription can improve the disequilibrium of prostaglandin, plasminogen system, hemorheology etc. pathological changes. Radix notoginseng and Radix rubiae were necessary ingredients in it.
Key words:endometrorrhagia caused by IUD-wearing; Radix notoginseng,Radix rubiae; 6-K-PGF1α;TXB2;t-PA
收稿日期:2009-11-19
基金项目:国家中医药管理局新药开发专项基金项目(D1X046B)
作者简介:谭朝阳(1970-),男,湖南郴州人,副教授,博士,主要从事中药制剂与质量的研究。
通讯作者:尤昭玲(1949-),女,湖南湘潭人,教授,博士研究生导师,主要从事妇科血症防治的研究。
宫内节育器(intrauterine device,IUD)具有避孕效果好、安全、简便、经济、长效及取器后不影响生育的特点,因此,广泛被育龄妇女接受和采用。但置器后所致的经期延长、月经量多等子宫异常出血反应是困扰置器者的主要问题,亦是影响其续用率的主要原因。中医对本病病因病机的认识己基本趋于一致[1],其病因病机多认为是环卧胞宫,冲任两脉及胞脉胞络为金刃所伤,脉络受损,血溢脉外,局部气血失和,脉络瘀阻,血不归经而妄行。“瘀”是本病症结所在,并贯穿病变始终,故以活血化瘀法组成三七茜草(SQ)复方进行防治,取得了较好的临床效果 ......
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