艾灸增强溃疡性结肠炎大鼠穴区HSP72和IL-6的表达(3)
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溃疡性结肠炎主要表现为肠道炎症反应,与免疫功能紊乱关系密切。值得注意的是,与正常组比较,UC模型组HSP72和IL-6表达均降低,且阳性目标总面积均有统计学意义(P<0.05,P<0.01),表明造模后,穴区皮肤免疫状态改变,可能与中医理论腧穴是人体气血出入的场所,可反映脏腑的功能相关。
从结肠黏膜HE染色结果,我们可以看出,艾灸对UC具有治疗作用,与前期研究结果一致[18-19]。表明艾灸可通过刺激穴位,达到治疗UC的作用。艾灸前后穴区HSP72和IL-6产生的相应变化,表明艾灸可能通过改变穴区某些物质的功能状态,刺激相关作用途径,达到治疗疾病的作用。
结合不同灸量对穴区HSP72和IL-6的综合影响,以及结肠黏膜HE染色结果,艾灸B组的艾灸刺激量可同时显著增强HSP72和IL-6的表达,改善结肠黏膜组织形态学结构,笔者认为,艾灸B组的艾灸刺激量可能是治疗的一个较佳灸量。
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