黄芪甲苷抑制高糖诱导的足细胞凋亡作用及机制(3)
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综上所述,笔者研究表明中药黄芪的主要药理成分AS-IV能显著缓解高糖所致的足细胞凋亡,其机制可能与AS-IV抗氧化及抑制p38-MAPK活化密切相关,因此,AS-IV可能成为防治早期DN的潜在新型中药单体,值得进一步研究和开发。
参考文献
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