论文下载：胰泰复方对慢性胰腺炎所致纤维化大鼠血清MDA含量血小板源性生

胰泰复方对慢性胰腺炎所致纤维化大鼠血清MDA含量血小板源性生长因子PDGF-B表达的影响(1)

http://www.100md.com 2010年4月1日陈馨馨1,周景华2,李友林3,刘华生4

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    参见附件。

     (1.北京中医药大学2008级博士研究生,北京 100029;2.黑龙江中医药大学附属医院,黑龙江哈尔滨 150040;

    3.中日友好医院国家中医药管理局重点研究室,北京 100029;4.黑龙江中医药大学基础医学院,黑龙江哈尔滨 150040)

    摘要:目的:观察中药胰泰复方对慢性胰腺炎胰腺纤维化大鼠血清丙二醛(MDA)和血小板源性生长因子B(PDGF-B)表达的影响。方法:以L-精氨酸左下腹腔注射制备大鼠慢性胰腺炎模型,予相应药物灌胃治疗,2个月后取血清用生化检测法测定MDA含量,取胰腺组织用免疫组织化学法测定PDGF-B的含量。结果:模型组MDA、PDGF-B含量明显高于空白组、中药对照组及中药治疗组,中药治疗组MDA、PDGF-B含量低于中药对照组。结论:胰泰复方能降低胰腺组织中MDA和PDGF-B的含量,对慢性胰腺炎胰腺纤维化具有恢复作用。

    关键词:胰泰复方;慢性胰腺炎;胰腺纤维化;血清丙二醛(MDA);血小板源性生长因子B(PDGF-B)

    中图分类号:R285.5 文献标识码:A 文章编号:1673-7717(2010)04-0825-03

    Effect of YITAI Compounded Medication on Expression of Maleic Dialdehyde

    And Platelet Derived Growth Factor-B of the Rats with Chronic Pancreatitis Fibrosis

    CHEN Xinxin 1, ZHOU Jinghua2,LI Youlin3,LIU Huasheng4

    (1.Medical Doctoral Student of 2008 of Beijing University of Chinese Medicine,Beijing 100029,China;

    2.Pathologicai Ward of Hospital Affiliated to Heilongjiang University of Traditional

    Chinese Medicine,Harbin 150040,Heilongjiang,China;

    3.Focus Investigatory office of China-Japan Friendship Hospital and State Administration of

    Traditional Chinese Medicine of the People's Republic of China,Beijing 100029,China;

    4.Basic medical College of Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,Heilongjiang,China.)

    Abstract:Objective:To investigate the influences of YITAI compounded medication on the expression of maleic dialdehyde and platelet derived growth factor-B of the model rats with chronic pancreatitis fibrosis.Methods:To establish the chronic pancreatitis rats model with L-arginine with the method of celia injection, we gave them YITAI compounded medication and collected serum and pancreas to check the contents of MDA and PDGF-B with the method of immune histochemistry.Results:The contents of MDA in serum and PDGF-B in model group was obviously higher than normal group,Chinese medicine control group and Chinese medicine treatment group,the contents of MDA in serum and PDGF-B in Chinese medicine treatment group was lower than Chinese medicine control group.Conclusion:YITAI Compounded

    Medication can decrease the contents of MDA in serum and PDGF-B in pancreas,so it plays an important role in the recovery of chronic pancreatitis fibrosis ......

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