活血利水法对兔外伤性玻璃体视网膜病变增殖膜上整合素β1表达的影响(1)
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摘 要：目的：探讨活血利水之散血明目片对外伤性增生性玻璃体视网膜病变(traumatic Proliferrative Vitreoretinopathy, tPVR)增殖膜(ERM)中整合素β1表达的影响及防治PVR的作用机理。方法：将40只成年有色家兔随机抽取32只，造成外伤性PVR模型，随机分成活血利水组、活血化瘀组、利水明目组、模型组，另8只为空白组。连续灌胃30天后，观察眼底PVR分级情况，免疫组织化学方法检测整合素β1表达在各组的表现及病理组织学改变。结果：在活血利水组,ERM中整合素β1阳性程度低于模型组，差异具有显著性(P<0.01)。活血化瘀组与利水明目组也能降低整合素β1表达的阳性程度，与模型组相比有显著性意义(P<0.05)。活血利水组整合素β1阳性程度低于另两个治疗组，有显著性差异(P<0.05)。活血利水治疗组整合素β1阳性程度略高于空白组，有显著差异性(P<0.01)。结论：活血利水法是活血化瘀和利水明目两者作用的协同，能通过拮抗增殖膜中整合素β1表达的作用来抑制增殖细胞的过度增生，从而防治PVR形成和发展。
关键词：活血利水法；散血明目片；外伤性增生性玻璃体视网膜病变；增殖膜(ERM)；整合素β1
中图分类号：R285.5 文献标识码：A 文章编号：1673-7717(2011)04-0722-04
Experimental Study of HuoXueLiShui Method on the Effects of Intergrin-β1’s
Expression on ERM of Traumatic Proliferative Vitreoretinopathy in Rabbits
FU Mei-lin 【sup】1，2【/sup】, PENG Qing-hua【sup】1【/sup】，CHEN Ji【sup】1，3【/sup】, XING Yan-fei【sup】1，4【/sup】
(1.Key Disciplinary of Ophthalmology Department of the First Affiliated Hospital of
Hunan University of Traditional Chinese Medicine，Changsha 410007，Hunan，China；
2.Department of Ophthalmology, Jili Hospital of Liuyang， Liuyang 410300，Hunan，China；
3.Department of Ophthalmology,Maternal and Children Health Hosptial of Yuhua District，Nanjing 210012，Jiangsu，China；
4.Department of Ophthalmology, TCM Hospital of Jiading District，Shanghai 201800,China)
Abstract:Objective: To study the curative and preventive effects and mechanism of HuoXueLiShui Method (HXLSM) on the effects of Intergrin-β1’s expression on ERM of Traumatic Proliferative Vitreoretinopathy.Methods: 32 rabbits were selected randomly from 40 healthy adult color rabbits and induced to traumatic proliferative vitreoretinopathy models, then divided into four groups: the first group was treated with San Xue Ming Mu Tablet-Huo Xue Li Shui (HXLS) group,the second treated with Zhi Xue Qu Yu Tablet-Huo Xue Hua Yu(HXHY) group,the third treated with Zhu Ling San-Li Shui Ming Mu(LSMM) group and the model group ......
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