【摘要】目的:研究产前应用乙肝免疫球蛋白预防乙型肝炎病毒宫内传播的疗效。方法:将120例单纯HBsAg阳性孕妇及65例HBsAg、HBeAg双阳性孕妇分别按照入院顺序各分为治疗组和对照组，治疗组孕妇妊娠28周、32周、36周各肌注HBIG200IU，对照组孕妇及新生儿仅随访观察。结果:不论HBeAg阴性或阳性，治疗组和对照组新生儿出生时HBV感染率无统计学差异，所有新生儿脐血anti-HBs均为阴性。结论:不论HBeAg阳性或阴性，HBsAg阳性孕妇产前应用乙肝免疫球蛋白对预防乙型肝炎病毒宫内传播无效，anti-HBs可能并不能通过母体传递给胎儿。

    【关键词】乙肝免疫球蛋白;乙型肝炎病毒;宫内传播

    Effectiveness study of Hepatitis B immunoglobulin for preventing intrauterine transmission of hepatitis B virus

    【Abstract】 Objective To assess the effectiveness of antepartum hepatitis B immunoglobulin administration for preventing intrauterine transmission of hepatitis B virus. Methods 120 HBsAg positive pregnant women and 65 both HBsAg and HBeAg positive pregnant women, in hospitalized order, were respectively divided into intervention groups and control groups. Subjects in the intervention groups received 200 IU hepatitis B immunoglobulin intramuscularly at 28, 32 and 36 weeks gestational age. Subjects in the control groups were only followed up. Results Whether HBeAg are positive or not, the neonatal hepatitis B infection rate difference between the intervention group and the control group was not statistically significant. Anti-HBs are negative in all the neonatal umbilical cord blood. Conclusion Antepartum three doses of hepatitis B immunoglobulin is not effective for preventing intrauterine transmission of hepatitis B virus. Anti-HBs may not be transmitted from mother to fetus. ......