严重脓毒症免疫调节的新策略：个体化评估和治疗(3)
[11] Gu W， Zeng L， Zhou J， et al. Clinical relevance of 13 cytokine gene polymorphisms in Chinese major trauma patients [J]. Intensive Care Med， 2010，36(7)：1261-1265.
[12] Song ZJ， Yin J， Yao CL， et al. Variants in the Toll-interacting protein gene are associated with the susceptibility to severe sepsis in the Chinese Han population [J]. Critical Care， 2011，15(1)： R12.
[13] Osuchowski MF， Welch K， Siddiqui J， et al. Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality [J]. J Immunol， 2006，177(3)：1967-1974.
, http://www.100md.com
[14] Yang HM， Yu Y， Chai JK， et al. Low HLA-DR expression on CD14+ monocytes of burn victims with sepsis， and the effect of carbachol in vitro [J]. Burns， 2008，34(8)：1158-1162.
[15] Calvano SE， Xiao W， Richards DR， et al. A network-based analysis of systemic inflammation in humans [J]. Nature， 2005，437(7061)：1032-1037.
[16] Wong HR， Cvijanovich N， Allen GL， et al. Genomic expression profiling across the pediatric systemic inflammatory response syndrome， sepsis， and septic shock spectrum [J]. Crit Care Med， 2009，37(5)：1558-1566.
, 百拇医药
[17] Buhimschi CS， Bhandari V， Han YW， et al. Using proteomics in perinatal and neonatal sepsis：hopes and challenges for the future [J]. Curr Opin Infect Dis， 2009， 22(3)：235-243.
[18] Vodovotz Y， Csete M， Bartels J， et al. Translational systems biology of inflammation [J]. Plos Comput Biol， 2008， 4(4)：e1000014.
[19] Vodovotz Y， Clermont G， Chow C， et al. Mathematical models of the acute inflammatory response [J]. Curr Opin Crit Care， 2004，10(5)：383-390.
, http://www.100md.com
[20] Dong X， Foteinou PT， Calvano SE， et al. Agent-based modeling of endotoxin-induced acute inflammatory response in human blood leukocytes [J]. PLoS One， 2010， 5(2)：e9249.
[21] Vodovotz Y， Chow CC， Bartels J， et al. In silico models of acute inflammation in animals [J]. Shock， 2006，26(3)：235-244.
[22] An G.In silico experiments of existing and hypothetical cytokine-directed clinical trials using agent-based modeling [J].Crit Care Med， 2004，32(10)：2050-2060.
, 百拇医药
[23] Meisel C， Schefold JC， Pschowski R， et al. Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression： a double-blind， randomized， placebo-controlled multicenter trial [J]. Am J Respir Crit Care Med， 2009，180(7)：640-648.
[24] Remmelts HH， Meijvis SC， Heijligenberg R， et al. Biomarkers define the clinical response to dexamethasone in community-acquired pneumonia [J]. J Infect， 2012， 65(1)：25-31.
, http://www.100md.com
[25] Clermont G， Bartels J， Kumar R， et al. In silico design of clinical trials： a method coming of age [J]. Crit Care Med，2004，32(10)：2061-2070.
(收稿日期：2013-02-08)
(本文编辑：何小军)
DOI：10.3760/cma.j.issn.1671-0282.2013.04.001
基金项目：国家自然科学基金 (81171837，81000023)
作者单位：200032 上海，复旦大学附属中山医院急诊科
通信作者：童朝阳， Email： tong.chaoyang@zs-hospital.sh.cn
P341-P343
, http://www.100md.com(宋振举 童朝阳)
[12] Song ZJ， Yin J， Yao CL， et al. Variants in the Toll-interacting protein gene are associated with the susceptibility to severe sepsis in the Chinese Han population [J]. Critical Care， 2011，15(1)： R12.
[13] Osuchowski MF， Welch K， Siddiqui J， et al. Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality [J]. J Immunol， 2006，177(3)：1967-1974.
, http://www.100md.com
[14] Yang HM， Yu Y， Chai JK， et al. Low HLA-DR expression on CD14+ monocytes of burn victims with sepsis， and the effect of carbachol in vitro [J]. Burns， 2008，34(8)：1158-1162.
[15] Calvano SE， Xiao W， Richards DR， et al. A network-based analysis of systemic inflammation in humans [J]. Nature， 2005，437(7061)：1032-1037.
[16] Wong HR， Cvijanovich N， Allen GL， et al. Genomic expression profiling across the pediatric systemic inflammatory response syndrome， sepsis， and septic shock spectrum [J]. Crit Care Med， 2009，37(5)：1558-1566.
, 百拇医药
[17] Buhimschi CS， Bhandari V， Han YW， et al. Using proteomics in perinatal and neonatal sepsis：hopes and challenges for the future [J]. Curr Opin Infect Dis， 2009， 22(3)：235-243.
[18] Vodovotz Y， Csete M， Bartels J， et al. Translational systems biology of inflammation [J]. Plos Comput Biol， 2008， 4(4)：e1000014.
[19] Vodovotz Y， Clermont G， Chow C， et al. Mathematical models of the acute inflammatory response [J]. Curr Opin Crit Care， 2004，10(5)：383-390.
, http://www.100md.com
[20] Dong X， Foteinou PT， Calvano SE， et al. Agent-based modeling of endotoxin-induced acute inflammatory response in human blood leukocytes [J]. PLoS One， 2010， 5(2)：e9249.
[21] Vodovotz Y， Chow CC， Bartels J， et al. In silico models of acute inflammation in animals [J]. Shock， 2006，26(3)：235-244.
[22] An G.In silico experiments of existing and hypothetical cytokine-directed clinical trials using agent-based modeling [J].Crit Care Med， 2004，32(10)：2050-2060.
, 百拇医药
[23] Meisel C， Schefold JC， Pschowski R， et al. Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression： a double-blind， randomized， placebo-controlled multicenter trial [J]. Am J Respir Crit Care Med， 2009，180(7)：640-648.
[24] Remmelts HH， Meijvis SC， Heijligenberg R， et al. Biomarkers define the clinical response to dexamethasone in community-acquired pneumonia [J]. J Infect， 2012， 65(1)：25-31.
, http://www.100md.com
[25] Clermont G， Bartels J， Kumar R， et al. In silico design of clinical trials： a method coming of age [J]. Crit Care Med，2004，32(10)：2061-2070.
(收稿日期：2013-02-08)
(本文编辑：何小军)
DOI：10.3760/cma.j.issn.1671-0282.2013.04.001
基金项目：国家自然科学基金 (81171837，81000023)
作者单位：200032 上海，复旦大学附属中山医院急诊科
通信作者：童朝阳， Email： tong.chaoyang@zs-hospital.sh.cn
P341-P343
, http://www.100md.com(宋振举 童朝阳)