弹性纤维与盆腔器官脱垂的研究进展(3)
综上所述,弹性纤维作为盆底结缔组织中重要组成成分,其稳态平衡对维持女性盆底结构和功能的完整性起着非常重要的作用,进一步研究女性POP中弹性蛋白基因或蛋白的表达变化、弹性纤维合成降解等,可更深入地探讨POP发病机制,为POP生物治疗提供新的靶点及思路,对该类疾病的防治具有重要意义。
[参考文献]
[1] 朱兰,郎景和.女性盆底学[M].北京:人民卫生出版社,2008:58-59.
[2] LSUSQUY R, COSTA P, DELMAS V, et al. Update on the epidemiology of genital prolapse[J]. Prog Urol, 2009, 19(13): 907-915.
[3] LEE U J, GUSTILO-ASHBY A M, DANESHGARI F, et al. Lower urogenital tract anatomical and functional phenotype in lysyl oxidase like-1 knockout mice resembles female pelvic floor dysfunction in humans[J]. Am J Physiol Renal Physiol, 2008, 295(2): F545-555.
, http://www.100md.com
[4] RAHN D D, ACEVEDO J F, ROSHANRAVAN S, et al. Failure of pelvic organ support in mice deficient in fibulin-3[J]. Am J Pathol, 2009, 174(1): 206 -215.
[5] DREWES P G, YANAGISAWA H, STARCHER B, et al. Pelvic organ prolapse in fibulin-5 knockout mice: pregnancy-induced changes in elastic fiber homeostasis in mouse vagina[J]. Am J Pathol, 2007, 170(2): 578-589.
[6] YANAGISAWA H, SCHLUTERMAN M K, BREKKEN R A. Fibulin-5, an integrin-binding matricellular protein: its function in development and disease[J]. J Cell Commun Signal, 2009, 3(3-4): 337-347.
, 百拇医药
[7] LEMAIER R, BAYLE J, MEEHAM R P, et al. Micorfibril-associated MAGP-2 Stimulates elastic fiber assembly[J]. J Biol Chem, 2007, 282(1): 800-808.
[8] CAIN S A, MCGOVERN A, SMALL E, et al. Defining elastic fiber interactions by molecular fishing: an affinity purification and mass spectrometry approach[J].Mol Cell Proteomics,2009, 8(12):2715-2732.
[9] ARGRAVES W S, GREENE L M, COOLEY M A, et al. Fibulins: physiological and disease perspectives[J]. BMBO Rep, 2003, 4(12): 1127-1131.
, 百拇医药
[10] 路顺,王培光,刘建军,等.遗传性皮肤松弛症的研究进展[J].中国麻风皮肤病杂志,2009,25(3):197-199.
[11] LIU X, ZHAO Y, GAO J, et al. Elastic fiber homeostasis requires lysyl oxidase-like l protein[J]. Nat Genet, 2004, 36(2): 178-182.
[12] LIU X, ZHAO Y, PAWLYK B, et al. Failure of elastic fiber homeostasis leads to pelvic floor disorders[J].Am J Pathol, 2006, 168(2):519-528.
[13] MAKI J M, SORNMNEN R, LIPPO S, et al. Lysyl oxidase isessential for normal development and functionof the respiratory system and for the integrity of elastic and collagen fibers ill various tissues[J]. Am J Pathol, 2005, 167(4):927-936.
, 百拇医药
[14] KLUTKE J, JI Q, CAMPEAU J, et al. Decreased endopelvic fascia elastin content in uterine prolapse[J]. Acta Obstet Gynecol Scand, 2008, 87(1): 111-115.
[15] BEHMOARAS J, SLOVE S, SEVE S, et al. Differential expression of lysyl oxidases LOXL1 and LOX during growth and aging suggests specific roles in elastin and collagen fiber remodeling in rat aorta[J]. Rejuvenation Res, 2008, 11(5): 883-889.
[16] KAGAN H M, LI W. Lysyi oxidase:properties, specificity, and biological roles inside and outside of the cell [J]. J Cell Biochem, 2003, 88(4):660-672.
, 百拇医药
[17] LUISETTI M, MA S, IADAROLA P, et al. Desmosine as a biomarker of elastin degradation in COPD: current status and future directions[J]. Eur Respir J, 2008, 32(5): 1146-1157.
[18] SDERBERG M W, BYSTRM B, KALAMAJSKI S, et al. Gene expressions of small leucine-rich repeat proteoglycans and fibulin-5 are decreased in pelvic organ prolapse[J]. Mol Hum Reprod, 2009,15(4): 251-257., 百拇医药(黄益娟, 龚 健)
[参考文献]
[1] 朱兰,郎景和.女性盆底学[M].北京:人民卫生出版社,2008:58-59.
[2] LSUSQUY R, COSTA P, DELMAS V, et al. Update on the epidemiology of genital prolapse[J]. Prog Urol, 2009, 19(13): 907-915.
[3] LEE U J, GUSTILO-ASHBY A M, DANESHGARI F, et al. Lower urogenital tract anatomical and functional phenotype in lysyl oxidase like-1 knockout mice resembles female pelvic floor dysfunction in humans[J]. Am J Physiol Renal Physiol, 2008, 295(2): F545-555.
, http://www.100md.com
[4] RAHN D D, ACEVEDO J F, ROSHANRAVAN S, et al. Failure of pelvic organ support in mice deficient in fibulin-3[J]. Am J Pathol, 2009, 174(1): 206 -215.
[5] DREWES P G, YANAGISAWA H, STARCHER B, et al. Pelvic organ prolapse in fibulin-5 knockout mice: pregnancy-induced changes in elastic fiber homeostasis in mouse vagina[J]. Am J Pathol, 2007, 170(2): 578-589.
[6] YANAGISAWA H, SCHLUTERMAN M K, BREKKEN R A. Fibulin-5, an integrin-binding matricellular protein: its function in development and disease[J]. J Cell Commun Signal, 2009, 3(3-4): 337-347.
, 百拇医药
[7] LEMAIER R, BAYLE J, MEEHAM R P, et al. Micorfibril-associated MAGP-2 Stimulates elastic fiber assembly[J]. J Biol Chem, 2007, 282(1): 800-808.
[8] CAIN S A, MCGOVERN A, SMALL E, et al. Defining elastic fiber interactions by molecular fishing: an affinity purification and mass spectrometry approach[J].Mol Cell Proteomics,2009, 8(12):2715-2732.
[9] ARGRAVES W S, GREENE L M, COOLEY M A, et al. Fibulins: physiological and disease perspectives[J]. BMBO Rep, 2003, 4(12): 1127-1131.
, 百拇医药
[10] 路顺,王培光,刘建军,等.遗传性皮肤松弛症的研究进展[J].中国麻风皮肤病杂志,2009,25(3):197-199.
[11] LIU X, ZHAO Y, GAO J, et al. Elastic fiber homeostasis requires lysyl oxidase-like l protein[J]. Nat Genet, 2004, 36(2): 178-182.
[12] LIU X, ZHAO Y, PAWLYK B, et al. Failure of elastic fiber homeostasis leads to pelvic floor disorders[J].Am J Pathol, 2006, 168(2):519-528.
[13] MAKI J M, SORNMNEN R, LIPPO S, et al. Lysyl oxidase isessential for normal development and functionof the respiratory system and for the integrity of elastic and collagen fibers ill various tissues[J]. Am J Pathol, 2005, 167(4):927-936.
, 百拇医药
[14] KLUTKE J, JI Q, CAMPEAU J, et al. Decreased endopelvic fascia elastin content in uterine prolapse[J]. Acta Obstet Gynecol Scand, 2008, 87(1): 111-115.
[15] BEHMOARAS J, SLOVE S, SEVE S, et al. Differential expression of lysyl oxidases LOXL1 and LOX during growth and aging suggests specific roles in elastin and collagen fiber remodeling in rat aorta[J]. Rejuvenation Res, 2008, 11(5): 883-889.
[16] KAGAN H M, LI W. Lysyi oxidase:properties, specificity, and biological roles inside and outside of the cell [J]. J Cell Biochem, 2003, 88(4):660-672.
, 百拇医药
[17] LUISETTI M, MA S, IADAROLA P, et al. Desmosine as a biomarker of elastin degradation in COPD: current status and future directions[J]. Eur Respir J, 2008, 32(5): 1146-1157.
[18] SDERBERG M W, BYSTRM B, KALAMAJSKI S, et al. Gene expressions of small leucine-rich repeat proteoglycans and fibulin-5 are decreased in pelvic organ prolapse[J]. Mol Hum Reprod, 2009,15(4): 251-257., 百拇医药(黄益娟, 龚 健)