急性脑梗死患者治疗前后血清NSE\NPY\IL-6和IL-8联合检测的临床意义
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[摘要] 目的:探讨了急性脑梗死患者治疗前后血清NSE、NPY、IL-6和IL-8水平的变化及临床意义。方法:应用放射免疫分析法对36例急性脑梗死患者进行了治疗前后血清NSE、NPY、IL-6和IL-8水平测定,并与35名正常健康人作比较。结果:急性脑梗死患者在治疗前血清NSE、NPY、IL-6和IL-8水平均非常显著地高于正常人组(P<0.01),经治疗2周后与正常人组比较仍有差异(P<0.05),且血清NSE水平与NPY、IL-6和IL-8水平呈正相关(r=0.5722,0.6014,0.5984,P<0.01)。结论:检测急性脑梗死患者血清NSE、NPY、IL-6和IL-8水平的变化,对判断病情和评价疗效均具有重要的临床价值。
[关健词] 急性脑梗死;神经元特异性烯醇化酶;神经肽Y;白细胞介素-6;白细胞介素-8
[Abstract] Objective To explore the clinical significance of changes of serum NSE、NPY、IL-6 and IL-8 levels after treatment in patients with acute cerebral infarction. Methods Serum NSE、NPY、IL-6 and IL-8 levels were determined with RIA in 36 patients after treatment in patients with acute cerebral infarction diseases and 35 controls . Results Before treatment , serum NSE、NPY、IL-6 and IL-8 levels in the patients were significantly higher than those in controls(P<0.01) ,after treatment for 2 weeks, the levels dropped markedly, but still remained significantly higher (P<0.05) .Serum NSE and serum NPY、 IL-6、IL-8 levels were mutually positively correlated (r=0 ......
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