RP-HPLC法测定苦参素在大鼠胃肠中的吸收动力学(1)

http://www.100md.com 2008年8月15日 徐　伟　沙　玫　张淑玲

第1页

    参见附件(1787KB，2页)。

     [摘要] 目的：研究苦参素在大鼠胃肠的吸收动力学特征。方法：采用大鼠在体胃肠吸收模型，以HPLC法测定胃肠灌注液中药物的含量。结果：苦参素在胃、十二指肠、空肠、回肠和结肠中的吸收百分率分别为(31.02±10.08)%、(21.13±2.71)%、(28.22±6.09)%、(35.66±9.01)%和(33.12±13.22)%。结论：苦参素在胃和小肠上段中吸收良好，制剂研究应考虑其吸收特征。

    [关键词] 苦参素；在体胃肠吸收；吸收动力学；高效液相色谱法

    [中图分类号]R969.1 [文献标识码]A [文章编号]1673-7210(2008)08(b)-011-02

    Study on the absorption kinetics of marine in rats′ stomachs and intestines by HPLC

    XU Wei, SHA Mei, ZHANG Shu-ling

    (Department of Pharmacy, Fujian College of Traditional Chinese Medicine, Fuzhou 350108, China)

    [Abstract] Objective: To study the absorption kinetics of marine in rats′ stomachs and intestines. Methods: The drug concentration by in situ perfusion in rats were determined by HPLC. Results: The absorption percentages of marine in stomach, duodenum, jejunum, ileum and colon were (31 ......

    http://www.100md.com/html/paper/1673-0089/2008/23/11.htm

您现在查看是摘要介绍页，详见PDF附件(1787KB，2页)。