血管内皮生长因子与微血管密度在良性前列腺增生中的表达(1)
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[摘要] 目的：探讨血管内皮生长因子(vascular endothelial growth factor, VEGF)与微血管密度(microvascular density, MVD)在良性前列腺增生(benign prostatic hyperplasia, BPH)中的表达情况及其在BPH血管生成中的作用。方法：应用VEGF、MVD的免疫组化S-P染色法分析23例BPH中VEGF及MVD的表达情况。结果：中央区VEGF表达阳性率为54.35%，周边区VEGF表达阳性率为13.48%，二者差别有高度统计学意义(P<0.01)；BPH中央区平均MVD值为(20.39±6.45)，周边区平均MVD值为(7.45±4.34)，二者差别有高度统计学意义(P<0.01)；BPH中VEGF表达强度与MVD值之间呈正相关(r=0.863 4，P<0.05)。结论：VEGF是促进BPH内血管生成的重要因素。
[关键词] 良性前列腺增生；血管内皮生长内子；微血管密度
[中图分类号] R697.32[文献标识码]C [文章编号]1673-7210(2008)09(a)-023-03
The expressions of vascular endothelial growth factor and microvascular density in benign prostatic hyperplasia
WANG Shi-li1, WANG Bin2, ZHANG Chao1, JI Hong-zhang1, WU Yue-mei1
(1.Department of Radiology, the Jiaozhou Central Hospital of Qingdao, Qingdao266300, China; 2.Department of Radiology, the Affiliated Hospital of Weifang Medical College, Weifang261042, China)
[Abstract] Objective：To investigate the expressions of vascular endothelial growth factor and microvascular density in benign prostatic hyperplasia, as well as the effects on the angiogenesis of BPH. Metheds：Immunohistochemical S-P assay was used to investigate the expressions of vascular endothelial growth factor and microvascular density in twenty-three cases of BPH. Results：The positive rates of VEGF in the center part and circumjacent part of BPH were 54.35% and 13.48% respectively, and it showed a significant difference(P
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