酒石酸长春瑞滨及其脂质体中药物的降解动力学研究(1)

http://www.100md.com 2009年8月15日 张伟明 邓英杰 顾吉晋 董晓东 周 妍

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     [摘要] 目的:考察长春瑞滨及其脂质体的稳定性与降解动力学。方法:考察光和热对长春瑞滨溶液及其脂质体中药物稳定性及降解动力学的影响,并拟合模型。结果:长春瑞滨溶液及其脂质体光降解均符合零级动力学;40℃热降解过程溶液组符合一级动力学,脂质体组符合零级动力学;60℃溶液组和脂质体组均符合一级动力学。结论:脂质体可显著提高长春瑞滨的光和热的稳定性。

    [关键词] 药剂学;脂质体;酒石酸长春瑞滨;降解动力学;稳定性

    [中图分类号] R94[文献标识码]A [文章编号]1673-7210(2009)08(b)-023-03

    The research on degradation kinetics of NVB solution and its liposome

    ZHANG Weiming, DENG Yingjie, GU Jijin, DONG Xiaodong, ZHOU Yan

    (School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China)

    [Abstract] Objective: To research the stability and degradation kinetics of NVB solution and its liposome. Methods: The light and thermal stabilities of NVB solution and its liposome were studied and the degradation kinetics was also investigated, the model was fit ......

    http://www.100md.com/html/paper/1673-0089/2009/23/11.htm

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