超敏C-反应蛋白在新生儿缺血缺氧性脑病诊断中的临床意义(1)
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[摘要] 目的:通过检测新生儿缺血缺氧性脑病(HIE)患儿中超敏C-反应蛋白(h-CRP)的变化,探讨其在HIE诊断中的作用。方法:选择46例HIE患儿为HIE组,选择同期正常足月新生儿21例为对照组,分别留取48 h内血清标本,并检测两组h-CRP浓度。结果:正常组与HIE组血清h-CRP浓度分别为(0.17±0.12) mg/dl与(1.74±0.67) mg/dl,两组比较,有显著性差异(t=2.631,P<0.05);轻度HIE组与中重度HIE组血清h-CRP浓度分别为(0.62±0.53) mg/dl与(2.11±0.82) mg/dl,两组比较,有非常显著性差异(t=2.316,P<0.01)。结论:血清h-CRP浓度作为生化指标,可提示HIE的发生,并能反映其严重程度。
[关键词] 超敏C-反应蛋白;新生儿缺血缺氧性脑病;诊断
[中图分类号] R722.1[文献标识码]A [文章编号]1673-7210(2010)05(b)-040-02
Clinical significance of high-sensitivity C-reactive protein in neonatal hypoxic-ischemic encephalopathy
SHAN Jili1, PANG Yanxi2, LI Tang1
(1.The Affiliated Hospital of Qingdao University Medical College, Qingdao 266000, China; 2.The Health Bureau of Gaomi City, Gaomi 261500, China)
[Abstract] Objective: To explore the role of high-sensitivity C-reactive protein (h-CRP) in the diagnosis of hypoxic-ischemic encephalopathy (HIE) by detecting the changes of h-CRP in neonatal HIE. Methods: 46 cases of HIE children were selected for the HIE group and 21 cases of normal full-term newborns over the same period were selected as the control group. The h-CRP concentration of two groups in 48 h serum samples were detected. Results: The serum h-CRP concentrations of normal group and the HIE group were (0.17±0.12) mg/dl and (1.74±0.67) mg/dl, there was a significant difference between the two groups (t=2.631, P<0.05). The serum h-CRP concentrations of mild HIE group and the group of moderate to severe HIE were (0.62±0.53) mg/dl and (2.11±0.82) mg/dl, there was a very significant difference between the two groups (t=2.316, P<0.01). Conclusion: The serum h-CRP concentration as a biochemical indicator can suggest the occurrence of HIE and reflect its severity.
[Key words] High-sensitivity C-reactive protein; Neonatal hypoxic-ischemic encephalopathy; Diagnosis
新生儿缺血缺氧性脑病(HIE)是儿科常见的急重症之一,有较高的致残率和死亡率,是导致智能发育迟缓和脑性瘫痪等儿童伤残的主要原因。当前对HIE的诊断主要依靠病史、临床表现及影像学检查,而没有一个定量的生化指标,故而不利于判断病情、动态推测病情变化、提供及时治疗及判断预后。如能够寻求到反映颅内组织病理损伤的一些特异性生化指标,有利于及时判断病情和判断预后,对HIE治疗有极其重要意义 ......
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