AnA\AnuA\抗Sm抗体\抗ds DNA抗体测定在诊断SLE中的作用(1)
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[摘要] 目的:通过检测抗核抗体(AnA)、抗核小体抗体(AnuA)、抗Sm抗体、抗ds DNA抗体,探讨它们在系统性红斑狼疮(SLE)中的诊断价值。方法:检测120例SLE患者中的AnA、AnuA、抗Sm抗体、抗ds DNA抗体水平,AnuA采用ELISA法测定,抗Sm抗体采用免疫斑点法测定,抗ds DNA抗体及AnA采用间接荧光免疫法测定。结果:在检测的120例SLE患者中,AnA、AnuA、抗Sm抗体、抗ds DNA抗体的阳性率分别为97.5%、85.0%、42.5%、45.0%,在结缔组织中的阳性率分别为77.6%、1.0%、2.0%、3.0%。健康对照组中的阳性率分别为15.0%、0、0、1.0%。AnA、AnuA、抗Sm抗体、抗ds DNA抗体的检测对SLE患者的诊断特异性分别为22.4%、99.0%、98.0%、96.9%。结论:AnuA对SLE患者的诊断特异性最高;AnA对SLE诊断的阳性率最高,但其特异性最低,AnuA、抗Sm抗体、抗ds DNA抗体测定都可作为SLE诊断的可靠指标。
[关键词] AnA;AnuA;抗Sm抗体;抗ds DNA抗体;SLE
[中图分类号] R593.24+1[文献标识码] B[文章编号] 1673-7210(2010)05(b)-077-02
Roles of AnA, AnuA, anti-Sm antibody and anti-ds DNA antibody in the diagnosis of SLE
HUANG Ping, LIANG Dongwei, ZHANG Zhenhong
(Department of Clinical Laboratory, the Second People's Hospital of Nanhai District, Foshan City, Guangdong Province, Foshan 528000, China)
[Abstract] Objective: To explore the roles of antinuclear antibody (AnA), anti-nucleosome antibody (AnuA), anti-Sm antibody and anti-ds DNA antibody in the diagnosis of systemic lupus erythematosus (SLE) by detecting their levels. Methods: The levels of AnA, AnuA, anti-Sm antibody and anti-ds DNA antibody in 120 patients with SLE were detected. AnuA was detected by using ELISA determination, anti-Sm antibody was detected by using immune dot determination, anti-ds DNA antibody and AnA were detected by using indirect fluorescent immunoassay. Results: In the detection of 120 patients with SLE, the positive rates of AnA, AnuA, anti-Sm antibody, anti-ds DNA antibody were 97.5%, 85.0%, 42.5%, 45.0% respectively; the positive rates in connective tissue were 77.6%, 1.0%, 2.0%, 3.0% respectively; the positive rates in healthy control group were 15.0%, 0, 0, 1.0% respectively. The specificity of AnA, AnuA, anti-Sm antibody, anti-ds DNA antibody in the diagnosis of patients with SLE were 22.4%, 99.0%, 98.0%, 96.9% respectively. Conclusion: AnuA shows the highest specificity for the diagnosis of SLE; AnA has a high positive rate in the diagnosis of SLE, but its specificity is the lowest, AnuA, anti-Sm antibody, anti-ds DNA antibody can serve as reliable indicators for the diagnosis of SLE ......
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